RAPGEF3 Antibody (PACO21293)
- SKU:
- PACO21293
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | RAPGEF3 Antibody (PACO21293) |
抗体コード: | PACO21293 |
サイズ: | 100ul(100ug) |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Recombinant protein of human RAPGEF3 |
憲法: | Liquid |
ストレージバッファ: | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts of various cell lines, using RAPGEF3 antibody. |
バックグラウンド: | EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signaling in part through protein kinase A (PKA). EPAC signaling plays a significant role in a number of cellular processes including migration and focal adhesion formation, exocytosis, insulin signaling axon growth and guidance and neurotransmitter release. |
シノニム: | RAPGEF3;CAMP-GEFI; EPAC; EPAC1; HSU79275; MGC21410; bcm910; |
UniProt Protein Function: | Epac1: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GEFs, misc.; GEFs Chromosomal Location of Human Ortholog: 12q13.1 Cellular Component: membrane; plasma membrane; endomembrane system; cAMP-dependent protein kinase complex Molecular Function:Rap guanyl-nucleotide exchange factor activity; protein binding; guanyl-nucleotide exchange factor activity; cAMP-dependent protein kinase regulator activity; cAMP binding Biological Process: positive regulation of syncytium formation by plasma membrane fusion; platelet activation; signal transduction; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein export from nucleus; cell proliferation; positive regulation of angiogenesis; cAMP-mediated signaling; positive regulation of stress fiber formation; energy reserve metabolic process; positive regulation of cAMP catabolic process; angiogenesis; blood coagulation; regulation of protein kinase activity; regulation of insulin secretion; Rap protein signal transduction |
UniProt Code: | O95398 |
NCBI GenInfo Identifier: | 317373593 |
NCBI Gene ID: | 10411 |
NCBI Accession: | O95398.6 |
UniProt Related Accession: | O95398 |
Molecular Weight: | |
NCBI Full Name: | Rap guanine nucleotide exchange factor 3 |
NCBI Synonym Full Names: | Rap guanine nucleotide exchange factor 3 |
NCBI Official Symbol: | RAPGEF3 |
NCBI Official Synonym Symbols: | EPAC; EPAC1; bcm910; HSU79275; CAMP-GEFI |
NCBI Protein Information: | rap guanine nucleotide exchange factor 3 |
UniProt Protein Name: | Rap guanine nucleotide exchange factor 3 |
UniProt Synonym Protein Names: | Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I |
UniProt Gene Name: | RAPGEF3 |
UniProt Entry Name: | RPGF3_HUMAN |
Antibodies | ELISA Kits |
Anti-RAPGEF3 Antibody (CAB2199) | Human EPAC1 (Exchange protein directly activated by cAMP 1) ELISA Kit (HUFI07944) |
Anti-Epac1 Antibody (CAB4149) | |
RAPGEF3 Antibody (PACO03341) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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