RAPGEF1 Antibody, HRP conjugated (PACO63416)
- SKU:
- PACO63416
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | RAPGEF1 Antibody, HRP conjugated (PACO63416) |
抗体コード: | PACO63416 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Peptide sequence from Human Rap guanine nucleotide exchange factor 1 protein (22-40AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. |
シノニム: | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G), RAPGEF1, GRF2 |
UniProt Protein Function: | RAPGEF1: an adaptor-type Src homology (SH)2-containing molecule. A guanine nucleotide releasing protein for Ras. Expressed ubiquitously in human adult and fetal tissues. Several alternatively spliced transcript variants have been described. |
UniProt Protein Details: | Protein type:GEFs; GEFs, Ras; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: cytosol; early endosome; endosome Molecular Function:protein binding; Rap guanyl-nucleotide exchange factor activity Biological Process: activation of MAPKK activity; positive regulation of GTPase activity; Rap protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway |
NCBI Summary: | This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13905 |
NCBI GenInfo Identifier: | 143811452 |
NCBI Gene ID: | 2889 |
NCBI Accession: | Q13905.3 |
UniProt Secondary Accession: | Q13905,Q5JUE4, Q68DL3, Q8IV73, |
UniProt Related Accession: | Q13905 |
Molecular Weight: | 122,287 Da |
NCBI Full Name: | Rap guanine nucleotide exchange factor 1 |
NCBI Synonym Full Names: | Rap guanine nucleotide exchange factor 1 |
NCBI Official Symbol: | RAPGEF1 |
NCBI Official Synonym Symbols: | C3G; GRF2 |
NCBI Protein Information: | rap guanine nucleotide exchange factor 1 |
UniProt Protein Name: | Rap guanine nucleotide exchange factor 1 |
UniProt Synonym Protein Names: | CRK SH3-binding GNRP; Guanine nucleotide-releasing factor 2; Protein C3G |
Protein Family: | Rap guanine nucleotide exchange factor |
UniProt Gene Name: | RAPGEF1 |
UniProt Entry Name: | RPGF1_HUMAN |