RAP1A Antibody (PACO14089)
- SKU:
- PACO14089
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | RAP1A Antibody (PACO14089) |
抗体コード: | PACO14089 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Full length fusion protein |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO14089(RAP1A Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue and A431 cell, Primary antibody: PACO14089(RAP1A Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO14089(RAP1A Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. |
シノニム: | RAP1A, member of RAS oncogene family |
UniProt Protein Function: | RAP1A: a small G protein of the Ras family with tumor suppressor activity. Induces morphological reversion of a cell line transformed by a Ras oncogene. Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Interacts with SGSM1, SGSM2 and SGSM3. |
UniProt Protein Details: | Protein type:Tumor suppressor; G protein, monomeric; Motility/polarity/chemotaxis; G protein; G protein, monomeric, Ras Chromosomal Location of Human Ortholog: 1p13.3 Cellular Component: neuron projection; perinuclear region of cytoplasm; late endosome; cytoplasm; early endosome; plasma membrane; cell junction; cytosol Molecular Function:GTPase activity; Rap guanyl-nucleotide exchange factor activity; protein binding; Ras GTPase binding; GTP binding; protein complex binding; protein transporter activity Biological Process: platelet activation; microvillus biogenesis; protein transport; nerve growth factor receptor signaling pathway; activation of MAPKK activity; positive regulation of protein kinase activity; energy reserve metabolic process; blood coagulation; signal transduction; regulation of insulin secretion; Rap protein signal transduction |
NCBI Summary: | This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
UniProt Code: | P62834 |
NCBI GenInfo Identifier: | 51338607 |
NCBI Gene ID: | 5906 |
NCBI Accession: | P62834.1 |
UniProt Secondary Accession: | P62834,P10113, |
UniProt Related Accession: | P62834 |
Molecular Weight: | 184 |
NCBI Full Name: | Ras-related protein Rap-1A |
NCBI Synonym Full Names: | RAP1A, member of RAS oncogene family |
NCBI Official Symbol: | RAP1A |
NCBI Official Synonym Symbols: | RAP1; C21KG; G-22K; KREV1; KREV-1; SMGP21 |
NCBI Protein Information: | ras-related protein Rap-1A; Ras-related protein Krev-1; GTP-binding protein smg p21A |
UniProt Protein Name: | Ras-related protein Rap-1A |
UniProt Synonym Protein Names: | C21KG; G-22K; GTP-binding protein smg p21A; Ras-related protein Krev-1 |
Protein Family: | Ras-related protein |
UniProt Gene Name: | RAP1A |
UniProt Entry Name: | RAP1A_HUMAN |
Antibodies | ELISA Kits |
Anti-RAP1A Antibody (CAB0975) | Human RAP1A ELISA Kit |
RAP1A Antibody (PACO11715) | Human Ras-related protein Rap-1A (RAP1A) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |