RAD51B Antibody (PACO04868)
- SKU:
- PACO04868
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RAD51B Antibody |
抗体コード: | PACO04868 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human, Mouse, Monkey |
免疫原: | synthesized peptide derived from the Internal region of human Rad51B. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | RAD51B; RAD51L1; REC2; DNA repair protein RAD51 homolog 2; R51H2; RAD51 homolog B; Rad51B; RAD51-like protein 1 |
UniProt Protein Function: | RAD51L1: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. The RAD51B- RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single- stranded gaps in duplex DNA and specifically to nicks in duplex DNA. A chromosomal aberration involving RAD51B is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23- 24) with HMGA1. A chromosomal aberration involving RAD51B is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with HMGA2. Belongs to the RecA family. RAD51 subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 14q23-q24.2 Cellular Component: nucleoplasm; replication fork; nucleus Molecular Function:DNA-dependent ATPase activity; protein binding; four-way junction DNA binding; DNA binding; double-stranded DNA binding; single-stranded DNA binding; ATP binding Biological Process: meiotic recombination; blood coagulation; DNA repair; double-strand break repair via homologous recombination; DNA recombination Disease: Leiomyoma, Uterine |
NCBI Summary: | The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Jul 2011] |
UniProt Code: | O15315 |
NCBI GenInfo Identifier: | 38258892 |
NCBI Gene ID: | 5890 |
NCBI Accession: | O15315.2 |
UniProt Secondary Accession: | O15315,O60914, O75210, Q3Y4F8, Q6FHX8, Q86SY3, Q86SY4 Q86TR0, Q86U92, Q86U93, Q86U94, Q8N6H4, |
UniProt Related Accession: | O15315 |
Molecular Weight: | 384 |
NCBI Full Name: | DNA repair protein RAD51 homolog 2 |
NCBI Synonym Full Names: | RAD51 paralog B |
NCBI Official Symbol: | RAD51B |
NCBI Official Synonym Symbols: | REC2; R51H2; RAD51L1 |
NCBI Protein Information: | DNA repair protein RAD51 homolog 2; RAD51 homolog B; RecA-like protein; recombination repair protein |
UniProt Protein Name: | DNA repair protein RAD51 homolog 2 |
UniProt Synonym Protein Names: | RAD51 homolog B; Rad51B; RAD51-like protein 1 |
UniProt Gene Name: | RAD51B |
UniProt Entry Name: | RA51B_HUMAN |