PTPMT1 Antibody, Biotin conjugated (PACO38057)
- SKU:
- PACO38057
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | PTPMT1 Antibody, Biotin conjugated (PACO38057) |
抗体コード: | PACO38057 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 protein (28-201AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic β cells. |
シノニム: | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (EC 3.1.3.27) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase) (Protein-tyrosine phosphatase mitochondrial 1) (EC 3.1.3.16) (EC 3.1.3.48), PTPMT1, MOSP PLIP |
UniProt Protein Function: | PTPMT1: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.1.3.16; EC 3.1.3.27; EC 3.1.3.48; Mitochondrial; Phosphatase, lipid; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: mitochondrion; nucleus Molecular Function:phosphatidylglycerophosphatase activity; phosphoinositide 5-phosphatase activity; protein binding Biological Process: cardiolipin biosynthetic process |
UniProt Code: | Q8WUK0 |
NCBI GenInfo Identifier: | 221218988 |
NCBI Gene ID: | 114971 |
NCBI Accession: | NP_001137456.1 |
UniProt Secondary Accession: | Q8WUK0,Q7Z557, Q96CR2, Q9BXV8, E9PAT8, |
UniProt Related Accession: | Q8WUK0 |
Molecular Weight: | 35.9kD |
NCBI Full Name: | phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform 2 |
NCBI Synonym Full Names: | protein tyrosine phosphatase, mitochondrial 1 |
NCBI Official Symbol: | PTPMT1 |
NCBI Official Synonym Symbols: | MOSP; PLIP; DUSP23; PNAS-129 |
NCBI Protein Information: | phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 |
UniProt Protein Name: | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 |
UniProt Synonym Protein Names: | PTEN-like phosphatase; Phosphoinositide lipid phosphatase; Protein-tyrosine phosphatase mitochondrial 1 (EC:3.1.3.16, EC:3.1.3.48) |
Protein Family: | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase |
UniProt Gene Name: | PTPMT1 |