PRDM5 Antibody, HRP conjugated (PACO58489)
- SKU:
- PACO58489
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | PRDM5 Antibody, HRP conjugated (PACO58489) |
抗体コード: | PACO58489 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human PR domain zinc finger protein 5 protein (29-111AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells. |
シノニム: | PR domain zinc finger protein 5 (EC 2.1.1) (PR domain-containing protein 5), PRDM5, PFM2 |
UniProt Protein Function: | PRDM5: Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells. Defects in PRDM5 are the cause of Brittle cornea syndrome type 2 (BCS2). A disorder characterized by extreme corneal thinning resulting in corneal rupture after minor trauma, blue sclerae, keratoconus or keratoglobus, hyperelasticity of the skin, and hypermobile joints. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Methyltransferase, protein lysine, predicted; DNA-binding; Transcription factor; C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 4q25-q26 Cellular Component: nucleus Molecular Function:protein binding; sequence-specific DNA binding Biological Process: histone deacetylation; histone H3-K9 methylation; mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent Disease: Brittle Cornea Syndrome 2 |
NCBI Summary: | The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NQX1 |
NCBI GenInfo Identifier: | 212276458 |
NCBI Gene ID: | 11107 |
NCBI Accession: | Q9NQX1.2 |
UniProt Secondary Accession: | Q9NQX1,Q0VAI9, Q0VAJ0, Q6NXQ7, |
UniProt Related Accession: | Q9NQX1 |
Molecular Weight: | 58,124 Da |
NCBI Full Name: | PR domain zinc finger protein 5 |
NCBI Synonym Full Names: | PR/SET domain 5 |
NCBI Official Symbol: | PRDM5 |
NCBI Official Synonym Symbols: | BCS2; PFM2 |
NCBI Protein Information: | PR domain zinc finger protein 5 |
UniProt Protein Name: | PR domain zinc finger protein 5 |
UniProt Synonym Protein Names: | PR domain-containing protein 5 |
Protein Family: | PR domain zinc finger protein |
UniProt Gene Name: | PRDM5 |
UniProt Entry Name: | PRDM5_HUMAN |