PPP6C Antibody (PACO51850)
- SKU:
- PACO51850
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PPP6C Antibody (PACO51850) |
抗体コード: | PACO51850 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Serine/threonine-protein phosphatase 6 catalytic subunit protein (40-211AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human spleen tissue using PACO51850 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO51850 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. |
シノニム: | Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed], PPP6C, PPP6 |
UniProt Protein Function: | PPP6C: a Ser/Thr phosphatase. A functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 9q33.3 Cellular Component: cytosol Molecular Function:protein binding; metal ion binding; protein serine/threonine phosphatase activity Biological Process: protein amino acid dephosphorylation; G1/S transition of mitotic cell cycle |
NCBI Summary: | This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00743 |
NCBI GenInfo Identifier: | 3183123 |
NCBI Gene ID: | 5537 |
NCBI Accession: | O00743.1 |
UniProt Secondary Accession: | O00743,Q9CQR6, Q64620, |
UniProt Related Accession: | O00743 |
Molecular Weight: | 305 |
NCBI Full Name: | Serine/threonine-protein phosphatase 6 catalytic subunit |
NCBI Synonym Full Names: | protein phosphatase 6, catalytic subunit |
NCBI Official Symbol: | PPP6C |
NCBI Official Synonym Symbols: | PP6; PP6C |
NCBI Protein Information: | serine/threonine-protein phosphatase 6 catalytic subunit; serine/threonine protein phosphatase catalytic subunit |
UniProt Protein Name: | Serine/threonine-protein phosphatase 6 catalytic subunit |
UniProt Gene Name: | PPP6C |
UniProt Entry Name: | PPP6_HUMAN |