PPIH Antibody (PACO29116)
- SKU:
- PACO29116
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PPIH Antibody (PACO29116) |
抗体コード: | PACO29116 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Peptidyl-prolyl cis-trans isomerase H protein (2-177AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: PPIH antibody at 8µg/ml + THP-1 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 20, 15 kDa Observed band size: 20 kDa . | |
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO29116 at dilution of 1:100. |
バックグラウンド: | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. |
シノニム: | Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP), PPIH, CYP20 CYPH |
UniProt Protein Function: | PPIH: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex. May act as a chaperone. Belongs to the cyclophilin-type PPIase family. PPIase H subfamily. |
UniProt Protein Details: | Protein type:Cyclophilin; EC 5.2.1.8; Isomerase; RNA processing; Spliceosome Chromosomal Location of Human Ortholog: 1p34.2 Cellular Component: cytoplasm; nuclear speck; nucleoplasm; spliceosome; U4/U6 x U5 tri-snRNP complex Molecular Function:cyclosporin A binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; ribonucleoprotein binding Biological Process: nuclear mRNA splicing, via spliceosome; positive regulation of viral genome replication; protein complex assembly |
NCBI Summary: | The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43447 |
NCBI GenInfo Identifier: | 37082225 |
NCBI Gene ID: | 10465 |
NCBI Accession: | O43447.1 |
UniProt Secondary Accession: | O43447,A6NNE7, |
UniProt Related Accession: | O43447 |
Molecular Weight: | 19kDa |
NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase H |
NCBI Synonym Full Names: | peptidylprolyl isomerase H |
NCBI Official Symbol: | PPIH |
NCBI Official Synonym Symbols: | CYPH; CYP-20; USA-CYP; SnuCyp-20 |
NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase H |
UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase H |
UniProt Synonym Protein Names: | Rotamase H; Small nuclear ribonucleoprotein particle-specific cyclophilin H; CypH; U-snRNP-associated cyclophilin SnuCyp-20; USA-CYP |
UniProt Gene Name: | PPIH |