PPIB Antibody (PACO16094)
- SKU:
- PACO16094
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PPIB Antibody (PACO16094) |
抗体コード: | PACO16094 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human PPIB |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16094(PPIB Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Human fetal liver tissue, 293T cells, human liver cancer tissue, hela cells, Primary antibody: PACO16094(PPIB Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO16094(PPIB Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. |
シノニム: | peptidylprolyl isomerase B (cyclophilin B) |
UniProt Protein Function: | PPIB: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9). OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients. Belongs to the cyclophilin-type PPIase family. PPIase B subfamily. |
UniProt Protein Details: | Protein type:Isomerase; Chaperone; EC 5.2.1.8; Secreted; Cyclophilin; Secreted, signal peptide; RNA-binding Chromosomal Location of Human Ortholog: 15q21-q22 Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; focal adhesion; melanosome; membrane; nucleus; perinuclear region of cytoplasm; smooth endoplasmic reticulum Molecular Function:collagen binding; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; protein complex binding; unfolded protein binding Biological Process: extracellular matrix organization and biogenesis; positive regulation of multicellular organism growth; protein peptidyl-prolyl isomerization; protein stabilization Disease: Osteogenesis Imperfecta, Type Ix |
NCBI Summary: | The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009] |
UniProt Code: | P23284 |
NCBI GenInfo Identifier: | 215273869 |
NCBI Gene ID: | 5479 |
NCBI Accession: | P23284.2 |
UniProt Secondary Accession: | P23284,Q6IBH5, Q9BVK5, A8K534, |
UniProt Related Accession: | P23284 |
Molecular Weight: | 23,743 Da |
NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase B |
NCBI Synonym Full Names: | peptidylprolyl isomerase B |
NCBI Official Symbol: | PPIB |
NCBI Official Synonym Symbols: | OI9; CYPB; SCYLP; CYP-S1; HEL-S-39 |
NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase B |
UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase B |
UniProt Synonym Protein Names: | CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP |
Protein Family: | Probable peptidyl-prolyl cis-trans isomerase |
UniProt Gene Name: | PPIB |
UniProt Entry Name: | PPIB_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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