PON3 Antibody, HRP conjugated (PACO57105)
- SKU:
- PACO57105
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
| 抗体名: | PON3 Antibody, HRP conjugated (PACO57105) |
| 抗体コード: | PACO57105 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Serum paraoxonase/lactonase 3 protein (269-335AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | HRP |
| バックグラウンド: | Has low activity towards the organophosphate paraxon and aromatic carboxylic acid, esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. |
| シノニム: | Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1), PON3 |
| UniProt Protein Function: | PON3: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. Belongs to the paraoxonase family. |
| UniProt Protein Details: | Protein type:EC 3.1.1.81; Secreted; EC 3.1.1.2; Hydrolase; Secreted, signal peptide; EC 3.1.8.1 Chromosomal Location of Human Ortholog: 7q21.3 Cellular Component: extracellular space Molecular Function:arylesterase activity; protein homodimerization activity Biological Process: aromatic compound catabolic process; carboxylic acid catabolic process; response to toxin |
| NCBI Summary: | This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15166 |
| NCBI GenInfo Identifier: | 50403778 |
| NCBI Gene ID: | 5446 |
| NCBI Accession: | Q15166.3 |
| UniProt Secondary Accession: | Q15166,O75855, O76060, Q6IRU9, Q8IX97, Q9BZH9, A4D1H8 |
| UniProt Related Accession: | Q15166 |
| Molecular Weight: | 39,607 Da |
| NCBI Full Name: | Serum paraoxonase/lactonase 3 |
| NCBI Synonym Full Names: | paraoxonase 3 |
| NCBI Official Symbol: | PON3 |
| NCBI Protein Information: | serum paraoxonase/lactonase 3 |
| UniProt Protein Name: | Serum paraoxonase/lactonase 3 |
| Protein Family: | Serum paraoxonase/lactonase |
| UniProt Gene Name: | PON3 |
| UniProt Entry Name: | PON3_HUMAN |
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