POLR2B Antibody (PACO13567)
- SKU:
- PACO13567
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | POLR2B Antibody (PACO13567) |
抗体コード: | PACO13567 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human POLR2B-Specific |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa;POLR2B;POL2RB;RPB2;hRPB140;hsRPB2 ; |
UniProt Protein Function: | POLR2B: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. Belongs to the RNA polymerase beta chain family. |
UniProt Protein Details: | Protein type:RNA splicing; Nucleotide Metabolism - pyrimidine; RNA-binding; EC 2.7.7.6; Transferase; Nucleotide Metabolism - purine; RNA processing; Transcription initiation complex Chromosomal Location of Human Ortholog: 4q12 Cellular Component: nucleoplasm; membrane; DNA-directed RNA polymerase II, core complex; nucleus Molecular Function:protein binding; DNA binding; ribonucleoside binding; metal ion binding; chromatin binding Biological Process: nuclear mRNA splicing, via spliceosome; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; mRNA capping; viral reproduction; somatic stem cell maintenance; nucleotide-excision repair; positive regulation of viral transcription; transcription-coupled nucleotide-excision repair; RNA splicing; RNA elongation from RNA polymerase II promoter; gene expression; DNA repair |
NCBI Summary: | This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
UniProt Code: | P30876 |
NCBI GenInfo Identifier: | 401012 |
NCBI Gene ID: | 5431 |
NCBI Accession: | P30876.1 |
UniProt Secondary Accession: | P30876,Q8IZ61, A8K1A8, |
UniProt Related Accession: | P30876,AAB23139 |
Molecular Weight: | 1174 |
NCBI Full Name: | DNA-directed RNA polymerase II subunit RPB2 |
NCBI Synonym Full Names: | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa |
NCBI Official Symbol: | POLR2B |
NCBI Official Synonym Symbols: | RPB2; POL2RB; hRPB140 |
NCBI Protein Information: | DNA-directed RNA polymerase II subunit RPB2; RNA polymerase II subunit 2; RNA polymerase II subunit B2; DNA-directed RNA polymerase II subunit B; RNA polymerase II second largest subunit; DNA-directed RNA polymerase II 140 kDa polypeptide |
UniProt Protein Name: | DNA-directed RNA polymerase II subunit RPB2 |
UniProt Synonym Protein Names: | DNA-directed RNA polymerase II 140 kDa polypeptide; DNA-directed RNA polymerase II subunit B; RNA polymerase II subunit 2; RNA polymerase II subunit B2 |
Protein Family: | DNA-directed RNA polymerase |
UniProt Gene Name: | POLR2B |
UniProt Entry Name: | RPB2_HUMAN |