PLAT Antibody (PACO18915)
- SKU:
- PACO18915
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PLAT Antibody (PACO18915) |
抗体コード: | PACO18915 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human |
免疫原: | Synthetic peptide of human PLAT |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 231 cells, Primary antibody: PACO18915(PLAT Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18915(PLAT Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. |
シノニム: | plasminogen activator, tissue |
UniProt Protein Function: | Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration. |
NCBI Summary: | This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
UniProt Code: | P00750 |
NCBI GenInfo Identifier: | 137119 |
NCBI Gene ID: | 5327 |
NCBI Accession: | P00750.1 |
UniProt Secondary Accession: | P00750,Q15103, Q503B0, Q6PJA5, Q7Z7N2, Q86YK8, Q9BU99 Q9BZW1, A8K022, B2R8E8, |
UniProt Related Accession: | P00750 |
Molecular Weight: | 44,373 Da |
NCBI Full Name: | Tissue-type plasminogen activator |
NCBI Synonym Full Names: | plasminogen activator, tissue type |
NCBI Official Symbol: | PLAT |
NCBI Official Synonym Symbols: | TPA; T-PA |
NCBI Protein Information: | tissue-type plasminogen activator |
UniProt Protein Name: | Tissue-type plasminogen activator |
UniProt Synonym Protein Names: | INN: Alteplase; INN: Reteplase |
Protein Family: | Taurine--pyruvate aminotransferase |
UniProt Gene Name: | PLAT |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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