PIM2 Antibody, HRP conjugated (PACO48127)
- SKU:
- PACO48127
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Description
抗体名: | PIM2 Antibody, HRP conjugated (PACO48127) |
抗体コード: | PACO48127 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Serine/threonine-protein kinase pim-2 protein (1-210AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate. |
シノニム: | Serine/threonine-protein kinase pim-2 (EC 2.7.11.1) (Pim-2h), PIM2 |
UniProt Protein Function: | Pim2: a Ca(2 )/calmodulin-dependent protein kinase of the PIM family. Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. |
UniProt Protein Details: | Protein type:Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Oncoprotein; EC 2.7.11.1; CAMK group; PIM family Chromosomal Location of Human Ortholog: Xp11.23 Cellular Component: cytoplasm Molecular Function:protein binding; protein serine/threonine kinase activity Biological Process: cell proliferation; G1/S transition of mitotic cell cycle; male meiosis; negative regulation of apoptosis; negative regulation of cell proliferation; positive regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein stabilization; regulation of mitotic cell cycle; response to virus |
NCBI Summary: | This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009] |
UniProt Code: | Q9P1W9 |
NCBI GenInfo Identifier: | 20139243 |
NCBI Gene ID: | 11040 |
NCBI Accession: | Q9P1W9.1 |
UniProt Secondary Accession: | Q9P1W9,Q99739, A8K4G6, |
UniProt Related Accession: | Q9P1W9 |
Molecular Weight: | 34,190 Da |
NCBI Full Name: | Serine/threonine-protein kinase pim-2 |
NCBI Synonym Full Names: | Pim-2 proto-oncogene, serine/threonine kinase |
NCBI Official Symbol: | PIM2 |
NCBI Protein Information: | serine/threonine-protein kinase pim-2 |
UniProt Protein Name: | Serine/threonine-protein kinase pim-2 |
UniProt Synonym Protein Names: | Pim-2h |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | PIM2 |
UniProt Entry Name: | PIM2_HUMAN |