UniProt Protein Function: | PIGP: Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Belongs to the PIGP family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Transferase; EC 2.4.1.198 Chromosomal Location of Human Ortholog: 21q22.2 Cellular Component: endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Molecular Function:phosphatidylinositol N-acetylglucosaminyltransferase activity Biological Process: preassembly of GPI anchor in ER membrane |
NCBI Summary: | This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016] |
UniProt Code: | P57054 |
NCBI GenInfo Identifier: | 425906062 |
NCBI Gene ID: | 51227 |
NCBI Accession: | P57054.3 |
UniProt Secondary Accession: | P57054,Q53Y28, Q96KI1, Q9NZA6, B2RB18, B2RE99, B5BU92 D3DSG7, J3KR75, |
UniProt Related Accession: | P57054 |
Molecular Weight: | 12,510 Da |
NCBI Full Name: | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P |
NCBI Synonym Full Names: | phosphatidylinositol glycan anchor biosynthesis class P |
NCBI Official Symbol: | PIGP |
NCBI Official Synonym Symbols: | DCRC; DSRC; DSCR5; PIG-P; DCRC-S |
NCBI Protein Information: | phosphatidylinositol N-acetylglucosaminyltransferase subunit P |
UniProt Protein Name: | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P |
UniProt Synonym Protein Names: | Down syndrome critical region protein 5; Down syndrome critical region protein C; Phosphatidylinositol-glycan biosynthesis class P protein; PIG-P |
UniProt Gene Name: | PIGP |
UniProt Entry Name: | PIGP_HUMAN |