PIAS4 Antibody, HRP conjugated (PACO61423)
- SKU:
- PACO61423
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | PIAS4 Antibody, HRP conjugated (PACO61423) |
抗体コード: | PACO61423 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human E3 SUMO-protein ligase PIAS4 protein (66-241AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. |
シノニム: | E3 SUMO-protein ligase PIAS4, PIASy, Protein inhibitor of activated STAT protein 4, Protein inhibitor of activated STAT protein gamma, PIAS-gamma, RING-type E3 ubiquitin transferase PIAS4, PIAS4, PIASG |
UniProt Protein Function: | PIAS4: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Interacts with AR, AXIN1, GATA2, LEF1, TP53 and STAT1 (IFNG-induced). Binds to AT-rich DNA sequences, known as matrix or scaffold attachment regions (MARs/SARs). Interacts with TICAM1. Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G(1) phase. Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes. Belongs to the PIAS family. |
UniProt Protein Details: | Protein type:SUMO conjugating system; Transcription, coactivator/corepressor; EC 6.3.2.-; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:protein binding; SUMO ligase activity; ubiquitin protein ligase binding Biological Process: double-strand break repair via nonhomologous end joining; negative regulation of transcription, DNA-dependent; positive regulation of protein sumoylation; protein sumoylation |
UniProt Code: | Q8N2W9 |
NCBI GenInfo Identifier: | 34922831 |
NCBI Gene ID: | 51588 |
NCBI Accession: | Q8N2W9.1 |
UniProt Secondary Accession: | Q8N2W9,O75926, Q96G19, Q9UN16, |
UniProt Related Accession: | Q8N2W9 |
Molecular Weight: | 56,504 Da |
NCBI Full Name: | E3 SUMO-protein ligase PIAS4 |
NCBI Synonym Full Names: | protein inhibitor of activated STAT 4 |
NCBI Official Symbol: | PIAS4 |
NCBI Official Synonym Symbols: | PIASY; Piasg; ZMIZ6; PIAS-gamma |
NCBI Protein Information: | E3 SUMO-protein ligase PIAS4 |
UniProt Protein Name: | E3 SUMO-protein ligase PIAS4 |
UniProt Synonym Protein Names: | PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; PIAS-gamma |
Protein Family: | E3 SUMO-protein ligase |
UniProt Gene Name: | PIAS4 |
UniProt Entry Name: | PIAS4_HUMAN |