Phospho-MAPK8/MAPK9/MAPK10 (Y185) Antibody (PACO00315)

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SKU:
PACO00315
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Application:
ELISA
Application:
WB
Application:
IHC
Antibody type:
Polyclonal
Conjugation:
Unconjugated
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Description

system_update_altデータシートsystem_update_alt安全性データシート
抗体名:Phospho-MAPK8/MAPK9/MAPK10 (Y185) Antibody
抗体コード:PACO00315
サイズ:50ug
宿主種:Rabbit
申し込み:ELISA, WB, IHC
推奨される希釈:WB:1:500-1:2000, IHC:1:100-1:300
反応性:Human, Mouse, Rat
免疫原:synthesized peptide derived from human JNK1/2/3 around the phosphorylation site of Y185.
憲法:Liquid
ストレージバッファ:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
精製方法:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
抗体のクローン性:Polyclonal
アイソタイプ:IgG
Conjugate:Non-conjugated
シノニム:MAPK8; JNK1; PRKM8; SAPK1; SAPK1C; Mitogen-activated protein kinase 8; MAP kinase 8; MAPK 8; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; MAPK9; JNK2; PRKM9; SAPK1A; Mi
UniProt Protein Function:JNK1: a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses, including UV and gamma radiation, ceramides, pro-inflammatory cytokines and, in some instances, by growth factors and GPCR agonists. Substrates include a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2, thus regulating AP-1 transcriptional activity. In T- cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Binds to at least four scaffolding proteins, JIP-1, -2, -3 and -4. Activity increased in obesity. Inhibition or mouse knockout increases insulin sensitivity. Part of NFB pathway involved in inflammation and cancer, and signals downstream of Ras, though possibly as an apoptotic negative regulator of growth. Four alternatively-spliced isoforms have been described.
UniProt Protein Details:

Protein type:Kinase, protein; EC 2.7.11.24; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); CMGC group; MAPK family; MAPK/JNK subfamily; JNK subfamily

Chromosomal Location of Human Ortholog: 10q11.22

Cellular Component: nucleoplasm; mitochondrion; cytosol; nucleus

Molecular Function:protein serine/threonine kinase activity; protein binding; enzyme binding; histone deacetylase regulator activity; histone deacetylase binding; JUN kinase activity; ATP binding

Biological Process: nerve growth factor receptor signaling pathway; apoptosis; positive regulation of apoptosis; rhythmic process; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of protein localization; regulation of transcription factor activity; response to stress; JNK cascade; negative regulation of protein binding; toll-like receptor 4 signaling pathway; response to UV; ossification; regulation of histone deacetylation; MyD88-independent toll-like receptor signaling pathway; peptidyl-threonine phosphorylation; regulation of circadian rhythm; JUN phosphorylation; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; response to cadmium ion; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; negative regulation of apoptosis

NCBI Summary:The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]
UniProt Code:P45983
NCBI GenInfo Identifier:2507195
NCBI Gene ID:5599
NCBI Accession:P45983.2
UniProt Secondary Accession:P45983,Q15709, Q15712, Q15713, Q308M2, B5BTZ5, B7ZLV4 D3DX88, D3DX92,
UniProt Related Accession:P45983
Molecular Weight:427
NCBI Full Name:Mitogen-activated protein kinase 8
NCBI Synonym Full Names:mitogen-activated protein kinase 8
NCBI Official Symbol:MAPK8  
NCBI Official Synonym Symbols:JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2  
NCBI Protein Information:mitogen-activated protein kinase 8; MAP kinase 8; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; stress-activated protein kinase 1c; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kin
UniProt Protein Name:Mitogen-activated protein kinase 8
UniProt Synonym Protein Names:JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1
Protein Family:JNK-interacting protein
UniProt Gene Name:MAPK8  
UniProt Entry Name:MK08_HUMAN
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