Phospho-EPS15 (Y849) Antibody (PACO02662)
- SKU:
- PACO02662
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | Phospho-EPS15 (Y849) Antibody |
抗体コード: | PACO02662 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | WB:1:500-1:2000 |
反応性: | Human, Mouse, Rat |
免疫原: | synthesized peptide derived from human Eps15 around the phosphorylation site of Y849. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | EPS15; AF1P; Epidermal growth factor receptor substrate 15; Protein Eps15; Protein AF-1p |
UniProt Protein Function: | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. |
NCBI Summary: | This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009] |
UniProt Code: | P42566 |
NCBI GenInfo Identifier: | 67476728 |
NCBI Gene ID: | 2060 |
NCBI Accession: | P42566.2 |
UniProt Secondary Accession: | P42566,Q5SRH4, B2R8J7, D3DPJ2, |
UniProt Related Accession: | P42566 |
Molecular Weight: | 99kDa |
NCBI Full Name: | Epidermal growth factor receptor substrate 15 |
NCBI Synonym Full Names: | epidermal growth factor receptor pathway substrate 15 |
NCBI Official Symbol: | EPS15 |
NCBI Official Synonym Symbols: | AF1P; AF-1P; MLLT5 |
NCBI Protein Information: | epidermal growth factor receptor substrate 15 |
UniProt Protein Name: | Epidermal growth factor receptor substrate 15 |
UniProt Synonym Protein Names: | Protein AF-1p |
Protein Family: | Epidermal growth factor receptor substrate |
UniProt Gene Name: | EPS15 |