Phospho-EPHA3/EPHA4/EPHA5 (Y779/833) Antibody (PACO03625)

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SKU:
PACO03625
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Application:
ELISA
Application:
IHC
Antibody type:
Polyclonal
Conjugation:
Unconjugated
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Description

system_update_altデータシートsystem_update_alt安全性データシート
抗体名:Phospho-EPHA3/EPHA4/EPHA5 (Y779/833) Antibody
抗体コード:PACO03625
サイズ:50ug
宿主種:Rabbit
申し込み:ELISA, IHC
推奨される希釈:IHC:1:100-1:300
反応性:Human, Mouse, Rat
免疫原:synthesized peptide derived from human EphA3/4/5 around the phosphorylation site of Y779/833.
憲法:Liquid
ストレージバッファ:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
精製方法:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
抗体のクローン性:Polyclonal
アイソタイプ:IgG
Conjugate:Non-conjugated
シノニム:EPHA3; ETK; ETK1; HEK; TYRO4; Ephrin type-A receptor 3; EPH-like kinase 4; EK4; hEK4; HEK; Human embryo kinase; Tyrosine-protein kinase TYRO4; Tyrosine-protein kinase receptor ETK1; Eph-like tyrosine kinase 1; EPHA4; HEK8; SEK; TYRO1; Ephri
UniProt Protein Function:EphA3: a receptor tyrosine kinase of the Eph family. Receptor for members of the ephrin-A family: binds to ephrin-A2, -A3, -A4 and -A5The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Two point mutations seen in a survey of colorectal tumors. Soluble receptors reduce tumor growth and angiogenesis in mouse models. Two alternatively spliced isoforms of EphA3 have been described.
UniProt Protein Details:

Protein type:EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; Kinase, protein; TK group; Eph family

Chromosomal Location of Human Ortholog: 3p11.2

Cellular Component: early endosome; extracellular region; integral to plasma membrane; plasma membrane

Molecular Function:ATP binding; GPI-linked ephrin receptor activity; protein binding

Biological Process: cell adhesion; cell migration; ephrin receptor signaling pathway; peptidyl-tyrosine phosphorylation; regulation of actin cytoskeleton organization and biogenesis; regulation of focal adhesion formation; regulation of GTPase activity

NCBI Summary:This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P29320
NCBI GenInfo Identifier:116241351
NCBI Gene ID:2042
NCBI Accession:P29320.2
UniProt Secondary Accession:P29320,Q9H2V3, Q9H2V4,
UniProt Related Accession:P29320
Molecular Weight:60,946 Da
NCBI Full Name:Ephrin type-A receptor 3
NCBI Synonym Full Names:EPH receptor A3
NCBI Official Symbol:EPHA3  
NCBI Official Synonym Symbols:EK4; ETK; HEK; ETK1; HEK4; TYRO4  
NCBI Protein Information:ephrin type-A receptor 3
UniProt Protein Name:Ephrin type-A receptor 3
UniProt Synonym Protein Names:EPH-like kinase 4; EK4; hEK4; HEK; Human embryo kinase; Tyrosine-protein kinase TYRO4; Tyrosine-protein kinase receptor ETK1; Eph-like tyrosine kinase 1
Protein Family:Ephrin type-A receptor
UniProt Gene Name:EPHA3  
UniProt Entry Name:EPHA3_HUMAN
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