UniProt Protein Function: | PFKP: phosphofructokinase, platelet type. An ubiquitous metabolic enzyme involved in the synthesis and degradation of fructose 2,6-bisphosphate. Key control step of glycolysis. An allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate. Activity: ATP D-fructose 6-phosphate = ADP D-fructose 1,6-bisphosphate. The holoenzyme consists of 4 subunits. The liver and muscle enzymes are homo-tetramers of four liver or muscle isoforms, respectively. The red blood cell enzyme consists hetero-tetramers of the muscle and liver isoforms. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts. |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Carbohydrate Metabolism - galactose; Kinase, other; Carbohydrate Metabolism - fructose and mannose Chromosomal Location of Human Ortholog: 10p15.3-p15.2 Cellular Component: cytosol; membrane; nucleus Molecular Function:6-phosphofructokinase activity; protein complex binding |
NCBI Summary: | The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008] |
UniProt Code: | Q01813 |
NCBI GenInfo Identifier: | 1346355 |
NCBI Gene ID: | 5214 |
NCBI Accession: | Q01813.2 |
UniProt Secondary Accession: | Q01813,Q5VSR7, Q5VSR8, B3KS15, |
UniProt Related Accession: | Q01813 |
Molecular Weight: | 85596 Da |
NCBI Full Name: | ATP-dependent 6-phosphofructokinase, platelet type |
NCBI Synonym Full Names: | phosphofructokinase, platelet |
NCBI Official Symbol: | PFKP |
NCBI Official Synonym Symbols: | PFKF; PFK-C; PFK-P; ATP-PFK |
NCBI Protein Information: | ATP-dependent 6-phosphofructokinase, platelet type |
UniProt Protein Name: | ATP-dependent 6-phosphofructokinase, platelet type |
UniProt Synonym Protein Names: | 6-phosphofructokinase type C; Phosphofructo-1-kinase isozyme C; PFK-C; Phosphohexokinase |
Protein Family: | ATP-dependent 6-phosphofructokinase |
UniProt Gene Name: | PFKP |
UniProt Entry Name: | PFKAP_HUMAN |