PDX1 Antibody (PACO07503)
- SKU:
- PACO07503
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PDX1 Antibody (PACO07503) |
抗体コード: | PACO07503 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | human PDX1 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
バックグラウンド: | Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the β-cell. |
シノニム: | PDX-1,Glucose-sensitive factor,GSF,Insulin promoter factor 1,IPF-1,Insulin upstream factor 1,IUF-1,Islet/duodenum homeobox-1, IDX-1,Somatostatin-transactivating factor 1,STF-1,PDX1,IPF1, STF1 |
UniProt Protein Function: | PDX1: Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP. Interacts with the methyltransferase SETD7. Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells). Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 13q12.1 Molecular Function:transcription factor activity Biological Process: detection of glucose; generation of precursor metabolites and energy; insulin secretion; nitric oxide mediated signal transduction; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter Disease: Diabetes Mellitus, Noninsulin-dependent; Diabetes Mellitus, Permanent Neonatal; Maturity-onset Diabetes Of The Young, Type 4; Pancreatic Agenesis 1 |
NCBI Summary: | The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008] |
UniProt Code: | P52945 |
NCBI GenInfo Identifier: | 1708540 |
NCBI Gene ID: | 3651 |
NCBI Accession: | P52945.1 |
UniProt Secondary Accession: | P52945,O60594, Q5VYW2, |
UniProt Related Accession: | P52945 |
Molecular Weight: | 30,771 Da |
NCBI Full Name: | Pancreas/duodenum homeobox protein 1 |
NCBI Synonym Full Names: | pancreatic and duodenal homeobox 1 |
NCBI Official Symbol: | PDX1 |
NCBI Official Synonym Symbols: | GSF; IPF1; IUF1; IDX-1; MODY4; PDX-1; STF-1; PAGEN1 |
NCBI Protein Information: | pancreas/duodenum homeobox protein 1 |
UniProt Protein Name: | Pancreas/duodenum homeobox protein 1 |
UniProt Synonym Protein Names: | Glucose-sensitive factor; GSF; Insulin promoter factor 1; IPF-1; Insulin upstream factor 1; IUF-1; Islet/duodenum homeobox-1; IDX-1; Somatostatin-transactivating factor 1; STF-1 |
Protein Family: | Pyridoxal 5'-phosphate synthase |
UniProt Gene Name: | PDX1 |
UniProt Entry Name: | PDX1_HUMAN |