バックグラウンド: | Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes. Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes. Together with PEF1, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats. In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification. Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Promotes localization and polymerization of TFG at endoplasmic reticulum exit site. Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca2+-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway. In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution. |
シノニム: | Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2), PDCD6, ALG2 |
UniProt Protein Function: | PDCD6: Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway. Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5p15.33 Cellular Component: endoplasmic reticulum membrane; nuclear membrane; endoplasmic reticulum; cytoplasm; cytoplasmic vesicle; nucleus; endosome Molecular Function:protein dimerization activity; protein binding; protein homodimerization activity; protein anchor; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding; calcium-dependent protein binding; molecular adaptor activity Biological Process: caspase activation; intracellular protein transport; negative regulation of TOR signaling pathway; positive regulation of angiogenesis; negative regulation of protein kinase B signaling cascade; negative regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of caspase activity; positive regulation of endothelial cell proliferation; angiogenesis; proteolysis; response to calcium ion |
NCBI Summary: | This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012] |
UniProt Code: | O75340 |
NCBI GenInfo Identifier: | 12230420 |
NCBI Gene ID: | 10016 |
NCBI Accession: | O75340.1 |
UniProt Secondary Accession: | O75340,Q2YDC2, Q5TZS0, B2RD16, E7ESR3, |
UniProt Related Accession: | O75340 |
Molecular Weight: | 191 |
NCBI Full Name: | Programmed cell death protein 6 |
NCBI Synonym Full Names: | programmed cell death 6 |
NCBI Official Symbol: | PDCD6 |
NCBI Official Synonym Symbols: | ALG2; ALG-2; PEF1B |
NCBI Protein Information: | programmed cell death protein 6; apoptosis-linked gene 2 protein; probable calcium-binding protein ALG-2 |
UniProt Protein Name: | Programmed cell death protein 6 |
UniProt Synonym Protein Names: | Apoptosis-linked gene 2 protein; Probable calcium-binding protein ALG-2 |
Protein Family: | Programmed cell death protein |
UniProt Gene Name: | PDCD6 |
UniProt Entry Name: | PDCD6_HUMAN |