PBX1 Antibody, HRP conjugated (PACO55711)
- SKU:
- PACO55711
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Description
抗体名: | PBX1 Antibody, HRP conjugated (PACO55711) |
抗体コード: | PACO55711 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Pre-B-cell leukemia transcription factor 1 protein (315-430AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity). |
シノニム: | Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL), PBX1, PRL |
UniProt Protein Function: | PBX1: Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Forms a heterodimer with MEIS1 which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10. Interacts with PBXIP1. Expressed in all tissues except in cells of the B and T lineage. Belongs to the TALE/PBX homeobox family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding; Oncoprotein; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1q23 Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus Molecular Function:protein binding; DNA binding; protein heterodimerization activity; transcription factor binding; transcription factor activity Biological Process: spleen development; transcription, DNA-dependent; thymus development; embryonic hemopoiesis; somatic stem cell maintenance; adrenal gland development; negative regulation of transcription factor activity; embryonic skeletal development; anterior/posterior pattern formation; negative regulation of neuron differentiation; ureteric bud branching; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of ossification; steroid biosynthetic process; sex differentiation; proximal/distal pattern formation; embryonic limb morphogenesis |
NCBI Summary: | This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017] |
UniProt Code: | P40424 |
NCBI GenInfo Identifier: | 730279 |
NCBI Gene ID: | 5087 |
NCBI Accession: | P40424.1 |
UniProt Related Accession: | P40424 |
Molecular Weight: | 38kDa; 46kDa |
NCBI Full Name: | Pre-B-cell leukemia transcription factor 1 |
NCBI Synonym Full Names: | PBX homeobox 1 |
NCBI Official Symbol: | PBX1 |
NCBI Official Synonym Symbols: | CAKUHED |
NCBI Protein Information: | pre-B-cell leukemia transcription factor 1 |
UniProt Protein Name: | Pre-B-cell leukemia transcription factor 1 |
UniProt Synonym Protein Names: | Homeobox protein PBX1; Homeobox protein PRL |
Protein Family: | Pre-B-cell leukemia transcription factor |
UniProt Gene Name: | PBX1 |
UniProt Entry Name: | PBX1_HUMAN |