PAX3 Antibody (PACO28814)
- SKU:
- PACO28814
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PAX3 Antibody (PACO28814) |
抗体コード: | PACO28814 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Paired box protein Pax-3 protein (90-184AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot Positive WB detected in: A2780 whole cell lysate, A375 whole cell lysate All lanes: PAX3 antibody at 5.3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 53, 25, 23, 45, 46, 54, 56 kDa Observed band size: 53 kDa . | |
Immunohistochemistry of paraffin-embedded human lung cancer using PACO28814 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human skin tissue using PACO28814 at dilution of 1:100. |
バックグラウンド: | Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. |
シノニム: | Paired box protein Pax-3 (HuP2), PAX3, HUP2 |
UniProt Protein Function: | PAX3: Probable transcription factor associated with development of alveolar rhabdomyosarcoma. Can bind to DNA as a heterodimer with PAX7. Interacts with DAXX. Belongs to the paired homeobox family. 7 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription factor; Oncoprotein; DNA-binding Chromosomal Location of Human Ortholog: 2q35 Cellular Component: nucleoplasm Molecular Function:protein binding; sequence-specific DNA binding Biological Process: apoptosis; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; sensory perception of sound; transcription from RNA polymerase II promoter Disease: Craniofacial-deafness-hand Syndrome; Rhabdomyosarcoma 2; Waardenburg Syndrome, Type 1; Waardenburg Syndrome, Type 3 |
NCBI Summary: | This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq, Jul 2008] |
UniProt Code: | P23760 |
NCBI GenInfo Identifier: | 1172022 |
NCBI Gene ID: | 5077 |
NCBI Accession: | P23760.2 |
UniProt Secondary Accession: | P23760,Q16448, Q494Z3, Q494Z4, Q53T90, Q6GSJ9, Q86UQ2 Q86UQ3, G5E9C1, |
UniProt Related Accession: | P23760 |
Molecular Weight: | 55,975 Da |
NCBI Full Name: | Paired box protein Pax-3 |
NCBI Synonym Full Names: | paired box 3 |
NCBI Official Symbol: | PAX3 |
NCBI Official Synonym Symbols: | WS1; WS3; CDHS; HUP2 |
NCBI Protein Information: | paired box protein Pax-3 |
UniProt Protein Name: | Paired box protein Pax-3 |
UniProt Synonym Protein Names: | HuP2 |
Protein Family: | Paired box protein |
UniProt Gene Name: | PAX3 |
UniProt Entry Name: | PAX3_HUMAN |