P2RX4 Antibody (PACO11037)
- SKU:
- PACO11037
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | P2RX4 Antibody (PACO11037) |
抗体コード: | PACO11037 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human P2RX4 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | purinergic receptor P2X, ligand-gated ion channel, 4;P2RX4;P2X4;P2X4R ; |
UniProt Protein Function: | P2X4: Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. Belongs to the P2X receptor family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral Chromosomal Location of Human Ortholog: 12q24.32 Cellular Component: membrane; cell soma; perinuclear region of cytoplasm; apical part of cell; lysosomal membrane; integral to plasma membrane; postsynaptic density; dendritic spine; plasma membrane; terminal button; integral to nuclear inner membrane; cell junction Molecular Function:protein homodimerization activity; copper ion binding; zinc ion binding; cadherin binding; drug binding; ATP binding; purinergic nucleotide receptor activity; ATP-gated cation channel activity; receptor binding Biological Process: positive regulation of nitric oxide biosynthetic process; generation of action potential; positive regulation of calcium-mediated signaling; regulation of sodium ion transport; sensory perception of pain; signal transduction; vasodilation; response to ATP; endothelial cell activation; membrane depolarization; transport; calcium ion transport; regulation of blood pressure; positive regulation of prostaglandin secretion; tissue homeostasis; regulation of excitatory postsynaptic membrane potential; positive regulation of calcium ion transport; nitric oxide biosynthetic process; protein homooligomerization |
NCBI Summary: | The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q99571 |
NCBI GenInfo Identifier: | 116242696 |
NCBI Gene ID: | 5025 |
NCBI Accession: | Q99571.2 |
UniProt Related Accession: | Q99571 |
Molecular Weight: | Predicted Molecular Mass: 33.2kDaAccurate Molecular Mass: 33kDa as determined by SDS-PAGE reducing conditions. |
NCBI Full Name: | P2X purinoceptor 4 |
NCBI Synonym Full Names: | purinergic receptor P2X 4 |
NCBI Official Symbol: | P2RX4 |
NCBI Official Synonym Symbols: | P2X4; P2X4R |
NCBI Protein Information: | P2X purinoceptor 4 |
UniProt Protein Name: | P2X purinoceptor 4 |
UniProt Synonym Protein Names: | ATP receptor; Purinergic receptor |
Protein Family: | P2X purinoceptor |
UniProt Gene Name: | P2RX4 |
UniProt Entry Name: | P2RX4_HUMAN |