P2RX1 Antibody (PACO49846)
- SKU:
- PACO49846
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | P2RX1 Antibody (PACO49846) |
抗体コード: | PACO49846 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human P2X purinoceptor 1 protein (54-175AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO49846 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO49846 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO49846 at dilution of 1:100. |
バックグラウンド: | Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity). |
シノニム: | P2X purinoceptor 1 (P2X1) (ATP receptor) (Purinergic receptor), P2RX1, P2X1 |
UniProt Protein Function: | P2X1: Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death. Belongs to the P2X receptor family. |
UniProt Protein Details: | Protein type:Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: integral to nuclear inner membrane; plasma membrane; secretory granule membrane Molecular Function:ATP-gated cation channel activity; cation channel activity; purinergic nucleotide receptor activity Biological Process: blood coagulation; ion transport; neutrophil degranulation; signal transduction; transport Disease: Bleeding Disorder, Platelet-type, 8 |
NCBI Summary: | The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013] |
UniProt Code: | P51575 |
NCBI GenInfo Identifier: | 1709519 |
NCBI Gene ID: | 5023 |
NCBI Accession: | P51575.1 |
UniProt Secondary Accession: | P51575,Q9UK84, |
UniProt Related Accession: | P51575 |
Molecular Weight: | 45kDa |
NCBI Full Name: | P2X purinoceptor 1 |
NCBI Synonym Full Names: | purinergic receptor P2X 1 |
NCBI Official Symbol: | P2RX1 |
NCBI Official Synonym Symbols: | P2X1 |
NCBI Protein Information: | P2X purinoceptor 1 |
UniProt Protein Name: | P2X purinoceptor 1 |
UniProt Synonym Protein Names: | ATP receptor; Purinergic receptor |
Protein Family: | P2X purinoceptor |
UniProt Gene Name: | P2RX1 |