OTX2 Antibody, Biotin conjugated (PACO28773)
- SKU:
- PACO28773
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | OTX2 Antibody, Biotin conjugated (PACO28773) |
抗体コード: | PACO28773 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Homeobox protein OTX2 protein (1-297AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. |
シノニム: | Homeobox protein OTX2 (Orthodenticle homolog 2), OTX2 |
UniProt Protein Function: | OTX2: Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. Expressed in brain. Belongs to the paired homeobox family. Bicoid subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 14q22.3 Cellular Component: growth cone; nucleus; protein complex Molecular Function:eukaryotic initiation factor 4E binding; protein binding Biological Process: axon guidance; forebrain development; midbrain development; positive regulation of embryonic development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein complex assembly; regulation of fibroblast growth factor receptor signaling pathway; regulation of smoothened signaling pathway Disease: Microphthalmia, Syndromic 5; Pituitary Hormone Deficiency, Combined, 6 |
NCBI Summary: | This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012] |
UniProt Code: | P32243 |
NCBI GenInfo Identifier: | 417427 |
NCBI Gene ID: | 5015 |
NCBI Accession: | P32243.1 |
UniProt Secondary Accession: | P32243,Q6GTV3, Q9HAW3, Q9P2R1, B2RAN5, |
UniProt Related Accession: | P32243 |
Molecular Weight: | 32,406 Da |
NCBI Full Name: | Homeobox protein OTX2 |
NCBI Synonym Full Names: | orthodenticle homeobox 2 |
NCBI Official Symbol: | OTX2 |
NCBI Official Synonym Symbols: | CPHD6; MCOPS5 |
NCBI Protein Information: | homeobox protein OTX2 |
UniProt Protein Name: | Homeobox protein OTX2 |
UniProt Synonym Protein Names: | Orthodenticle homolog 2 |
Protein Family: | Homeobox protein |
UniProt Gene Name: | OTX2 |