NUMBL Antibody (PACO21265)
- SKU:
- PACO21265
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NUMBL Antibody (PACO21265) |
抗体コード: | PACO21265 |
サイズ: | 100ul(100ug) |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: |
憲法: | Liquid |
ストレージバッファ: | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts of kidney cell lines, using NUMBL antibody. |
バックグラウンド: | Numb-like (Numbl or Nbl) binds Notch and is an intracellular modulator of Notch signaling pathway. Numbl contains a phosphotyrosine binding (PTB) domain that could bind the Y682 motif present in the cytoplasmic tail of APP. Deduced molecular weight of Numbl is 72 kDa. |
シノニム: | NUMBL; CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR; TNRC23 |
UniProt Protein Function: | NUMBL: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. Interacts (via PTB domain) with MAP3K7IP2 (via C- terminal). Interacts (via C-terminal) with TRAF6 (via TRAF domains). Associates with EPS15 and NOTCH1. |
UniProt Protein Details: | Protein type:Cell development/differentiation Chromosomal Location of Human Ortholog: 19q13.13-q13.2 Cellular Component: cytoplasm Molecular Function:protein binding Biological Process: nervous system development; positive regulation of neurogenesis; axonogenesis; cytokine and chemokine mediated signaling pathway; protein metabolic process; neuroblast division in the subventricular zone; positive regulation of dendrite morphogenesis; lateral ventricle development |
UniProt Code: | Q9Y6R0 |
NCBI GenInfo Identifier: | 14194976 |
NCBI Gene ID: | 9253 |
NCBI Accession: | Q9Y6R0.1 |
UniProt Secondary Accession: | Q9Y6R0,Q7Z4J9, |
UniProt Related Accession: | Q9Y6R0 |
Molecular Weight: | 609 |
NCBI Full Name: | Numb-like protein |
NCBI Synonym Full Names: | numb homolog (Drosophila)-like |
NCBI Official Symbol: | NUMBL |
NCBI Official Synonym Symbols: | NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE |
NCBI Protein Information: | numb-like protein; numb homolog-like; numb-related protein |
UniProt Protein Name: | Numb-like protein |
UniProt Synonym Protein Names: | Numb-related protein; Numb-R |
Protein Family: | Numb-like protein |
UniProt Gene Name: | NUMBL |
UniProt Entry Name: | NUMBL_HUMAN |