UniProt Protein Function: | ANPA: natriuretic peptide receptor A, which mediates natriuretic, diuretic, and vasorelaxing actions of the natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Has guanylate cyclase activity on binding of ANF. Hypertensive SHR Rat has polymorphism at the locus. Human non-coding polymorphisms can alter expression up to two-fold, and have been associated with hypertension. A coding SNP is associated with hypertension and myocardial infarction. |
UniProt Protein Details: | Protein type:Guanylyl cyclase; Protein kinase, RGC; Lyase; Protein kinase, dual-specificity (receptor); Nucleotide Metabolism - purine; Kinase, protein; EC 4.6.1.2; Receptor, misc.; Membrane protein, integral; RGC group; RGC family Chromosomal Location of Human Ortholog: 1q21-q22 Cellular Component: guanylate cyclase complex, soluble; integral to plasma membrane; plasma membrane; receptor complex Molecular Function:adenylate cyclase activity; ATP binding; GTP binding; guanylate cyclase activity; hormone binding; natriuretic peptide receptor activity; peptide hormone binding; peptide receptor activity, G-protein coupled; protein kinase activity; protein kinase binding Biological Process: body fluid secretion; cell surface receptor linked signal transduction; cGMP biosynthetic process; dopamine metabolic process; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; negative regulation of cell growth; negative regulation of smooth muscle cell proliferation; positive regulation of cGMP biosynthetic process; protein amino acid phosphorylation; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; regulation of vascular permeability; regulation of vasodilation |
NCBI Summary: | Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009] |
UniProt Code: | P16066 |
NCBI GenInfo Identifier: | 113912 |
NCBI Gene ID: | 4881 |
NCBI Accession: | P16066.1 |
UniProt Secondary Accession: | P16066,Q5SR08, Q6P4Q3, B0ZBF0, |
UniProt Related Accession: | P16066 |
Molecular Weight: | 118,919 Da |
NCBI Full Name: | Atrial natriuretic peptide receptor 1 |
NCBI Synonym Full Names: | natriuretic peptide receptor 1 |
NCBI Official Symbol: | NPR1 |
NCBI Official Synonym Symbols: | ANPa; NPRA; ANPRA; GUC2A; GUCY2A |
NCBI Protein Information: | atrial natriuretic peptide receptor 1 |
UniProt Protein Name: | Atrial natriuretic peptide receptor 1 |
UniProt Synonym Protein Names: | Atrial natriuretic peptide receptor type A; ANP-A; ANPR-A; NPR-A; Guanylate cyclase A; GC-A |
Protein Family: | Phosphoglucomutase |
UniProt Gene Name: | NPR1 |
UniProt Entry Name: | ANPRA_HUMAN |