Nox4 Antibody, Biotin conjugated (PACO28605)
- SKU:
- PACO28605
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | Nox4 Antibody, Biotin conjugated (PACO28605) |
抗体コード: | PACO28605 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Rat |
免疫原: | Recombinant Rat NADPH oxidase 4 protein (210-424AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. |
シノニム: | NADPH oxidase 4 (EC 1.6.3.-) (Kidney oxidase-1) (KOX-1) (Kidney superoxide-producing NADPH oxidase), Nox4, Kox |
UniProt Protein Function: | NOX4: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity. 7 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nucleolus; Membrane protein, integral; EC 1.6.3.-; Membrane protein, multi-pass; Cell cycle regulation; Oxidoreductase |
NCBI Summary: | enzyme involved in the production of reactive oxygen species in vascular smooth muscle cells [RGD, Feb 2006] |
UniProt Code: | Q924V1 |
NCBI GenInfo Identifier: | 16758288 |
NCBI Gene ID: | 85431 |
NCBI Accession: | NP_445976.1 |
UniProt Secondary Accession: | Q924V1,Q99M78, |
UniProt Related Accession: | Q924V1 |
Molecular Weight: | 38.6 kDa |
NCBI Full Name: | NADPH oxidase 4 |
NCBI Synonym Full Names: | NADPH oxidase 4 |
NCBI Official Symbol: | Nox4 |
NCBI Protein Information: | NADPH oxidase 4 |
UniProt Protein Name: | NADPH oxidase 4 |
UniProt Synonym Protein Names: | Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase |
Protein Family: | NADPH oxidase |
UniProt Gene Name: | Nox4 |
UniProt Entry Name: | NOX4_RAT |