NME8 Antibody (PACO17341)
- SKU:
- PACO17341
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NME8 Antibody (PACO17341) |
抗体コード: | PACO17341 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:30-1:150 |
反応性: | Human |
免疫原: | Fusion protein of human NME8 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17341(NME8 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6. |
シノニム: | NME/NM23 family member 8 |
UniProt Protein Function: | TXNDC3: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. Defects in NME8 are the cause of primary ciliary dyskinesia type 6 (CILD6). CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. |
UniProt Protein Details: | Protein type:Oxidoreductase; Kinase, nucleoside diphosphate; Other group; NDK family Chromosomal Location of Human Ortholog: 7p14.1 Cellular Component: cytoplasm; intracellular Molecular Function:nucleoside diphosphate kinase activity; ATP binding Biological Process: GTP biosynthetic process; CTP biosynthetic process; cell redox homeostasis; multicellular organismal development; UTP biosynthetic process; nucleoside diphosphate phosphorylation; spermatogenesis; cell differentiation Disease: Ciliary Dyskinesia, Primary, 6 |
NCBI Summary: | This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.[provided by RefSeq, Nov 2009] |
UniProt Code: | Q8N427 |
NCBI GenInfo Identifier: | 148839372 |
NCBI Gene ID: | 51314 |
NCBI Accession: | NP_057700.3 |
UniProt Secondary Accession: | Q8N427,Q9NZH1, |
UniProt Related Accession: | Q8N427 |
Molecular Weight: | 67,270 Da |
NCBI Full Name: | thioredoxin domain-containing protein 3 |
NCBI Synonym Full Names: | NME/NM23 family member 8 |
NCBI Official Symbol: | NME8 |
NCBI Official Synonym Symbols: | CILD6; SPTRX2; TXNDC3; NM23-H8; sptrx-2 |
NCBI Protein Information: | thioredoxin domain-containing protein 3 |
UniProt Protein Name: | Thioredoxin domain-containing protein 3 |
UniProt Synonym Protein Names: | NM23-H8; NME/NM23 family member 8; Spermatid-specific thioredoxin-2; Sptrx-2 |
Protein Family: | Thioredoxin domain-containing protein |
UniProt Gene Name: | NME8 |
UniProt Entry Name: | TXND3_HUMAN |