NGEF Antibody (PACO10844)
- SKU:
- PACO10844
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NGEF Antibody (PACO10844) |
抗体コード: | PACO10844 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human NGEF |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | neuronal guanine nucleotide exchange factor;NGEF;EPHEXIN ; |
UniProt Protein Function: | ephexin-1: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension. Interacts with CDK5R1 and EPHA4; activated by EPHA4 through the CDK5 kinase. Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GEFs, Rac/Rho; GEFs Chromosomal Location of Human Ortholog: 2q37 Cellular Component: cytosol Molecular Function:guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity Biological Process: ephrin receptor signaling pathway; positive regulation of apoptosis; regulation of GTPase activity; regulation of small GTPase mediated signal transduction |
UniProt Code: | Q8N5V2 |
NCBI GenInfo Identifier: | 114152090 |
NCBI Gene ID: | 25791 |
NCBI Accession: | Q8N5V2.2 |
UniProt Secondary Accession: | Q8N5V2,Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6, B4DMB8, B9A045 E9PC42, |
UniProt Related Accession: | Q8N5V2 |
Molecular Weight: | 71,387 Da |
NCBI Full Name: | Ephexin-1 |
NCBI Synonym Full Names: | neuronal guanine nucleotide exchange factor |
NCBI Official Symbol: | NGEF |
NCBI Official Synonym Symbols: | EPHEXIN; ARHGEF27 |
NCBI Protein Information: | ephexin-1 |
UniProt Protein Name: | Ephexin-1 |
UniProt Synonym Protein Names: | Eph-interacting exchange protein; Neuronal guanine nucleotide exchange factor |
Protein Family: | Ephexin |
UniProt Gene Name: | NGEF |
UniProt Entry Name: | NGEF_HUMAN |