NES Antibody (PACO49022)
- SKU:
- PACO49022
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NES Antibody (PACO49022) |
抗体コード: | PACO49022 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Nestin protein (1321-1569AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescent analysis of U251 cells using PACO49022 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunocytochemistry analysis of human kidney tissue using PACO49022 at dilution of 1:100. |
バックグラウンド: | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). |
シノニム: | Nestin, NES |
UniProt Protein Function: | nestin: an intermediate filament protein. It is expressed predominantly in stem cells of the central nervous system in the neural tube. Upon terminal neural differentiation, nestin is downregulated and replaced by neurofilaments. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 1q23.1 Cellular Component: intermediate filament cytoskeleton; cytoplasm; intermediate filament Molecular Function:intermediate filament binding; structural molecule activity Biological Process: positive regulation of intermediate filament depolymerization; central nervous system development; negative regulation of catalytic activity; cell projection morphogenesis; brain development; negative regulation of neuron apoptosis; negative regulation of protein binding; G2/M transition of mitotic cell cycle; embryonic camera-type eye development |
NCBI Summary: | This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011] |
UniProt Code: | P48681 |
NCBI GenInfo Identifier: | 146345464 |
NCBI Gene ID: | 10763 |
NCBI Accession: | P48681.2 |
UniProt Secondary Accession: | P48681,O00552, Q3LIF5, Q5SYZ6, |
UniProt Related Accession: | P48681 |
Molecular Weight: | 1621 |
NCBI Full Name: | Nestin |
NCBI Synonym Full Names: | nestin |
NCBI Official Symbol: | NES |
NCBI Official Synonym Symbols: | Nbla00170 |
NCBI Protein Information: | nestin |
UniProt Protein Name: | Nestin |
Protein Family: | Nestin |
UniProt Gene Name: | NES |
UniProt Entry Name: | NEST_HUMAN |