NDC80 Antibody, HRP conjugated (PACO46059)
- SKU:
- PACO46059
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | NDC80 Antibody, HRP conjugated (PACO46059) |
抗体コード: | PACO46059 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Kinetochore protein NDC80 homolog protein (1-249AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. |
シノニム: | Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC), NDC80, HEC HEC1 KNTC2 |
UniProt Protein Function: | HEC1: plays an essential role in chromosome segregation by interacting through its coiled-coil domains with several proteins that modulate the G2/M phase. Phosphorylation by Nek2 is essential for faithful chromosome segregation. Required for the recruitment of Mps1 kinase and Mad1/Mad2 complexes to kinetochores. |
UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 18p11.32 Cellular Component: chromosome, pericentric region; cytosol; kinetochore; membrane; nucleus Molecular Function:identical protein binding; protein binding; structural constituent of cytoskeleton Biological Process: attachment of spindle microtubules to kinetochore; attachment of spindle microtubules to kinetochore during mitosis; chromosome segregation; establishment of mitotic spindle orientation; mitosis; mitotic sister chromatid segregation; mitotic spindle organization and biogenesis; sister chromatid cohesion |
NCBI Summary: | This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011] |
UniProt Code: | O14777 |
NCBI GenInfo Identifier: | 74735330 |
NCBI Gene ID: | 10403 |
NCBI Accession: | O14777.1 |
UniProt Secondary Accession: | O14777,Q6PJX2, |
UniProt Related Accession: | O14777 |
Molecular Weight: | 73,913 Da |
NCBI Full Name: | Kinetochore protein NDC80 homolog |
NCBI Synonym Full Names: | NDC80, kinetochore complex component |
NCBI Official Symbol: | NDC80 |
NCBI Official Synonym Symbols: | HEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80 |
NCBI Protein Information: | kinetochore protein NDC80 homolog |
UniProt Protein Name: | Kinetochore protein NDC80 homolog |
UniProt Synonym Protein Names: | Highly expressed in cancer protein; Kinetochore protein Hec1; HsHec1; Kinetochore-associated protein 2; Retinoblastoma-associated protein HEC |
Protein Family: | Kinetochore protein |
UniProt Gene Name: | NDC80 |
UniProt Entry Name: | NDC80_HUMAN |