NCR3 Antibody (PACO54894)
- SKU:
- PACO54894
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NCR3 Antibody (PACO54894) |
抗体コード: | PACO54894 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Natural cytotoxicity triggering receptor 3 protein (19-135AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human lung cancer using PACO54894 at dilution of 1:100. | |
Immunofluorescence staining of HepG2 cells with PACO54894 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. |
シノニム: | Natural cytotoxicity triggering receptor 3 (Activating natural killer receptor p30) (Natural killer cell p30-related protein) (NK-p30) (NKp30) (CD antigen CD337), NCR3, 1C7 LY117 |
UniProt Protein Function: | NCR3: Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation. Belongs to the natural cytotoxicity receptor (NCR) family. 6 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Receptor, misc.; Apoptosis; Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: integral to plasma membrane Biological Process: cell recognition; immune response; inflammatory response; positive regulation of natural killer cell mediated cytotoxicity Disease: Malaria, Mild, Susceptibility To |
NCBI Summary: | The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010] |
UniProt Code: | O14931 |
NCBI GenInfo Identifier: | 47605770 |
NCBI Gene ID: | 259197 |
NCBI Accession: | O14931.1 |
UniProt Secondary Accession: | O14931,O14930, O14932, O95667, O95668, O95669, Q5ST89 Q5ST90, Q5ST91, B0S8F2, B0S8F4, B0S8F5, |
UniProt Related Accession: | O14931 |
Molecular Weight: | 201 |
NCBI Full Name: | Natural cytotoxicity triggering receptor 3 |
NCBI Synonym Full Names: | natural cytotoxicity triggering receptor 3 |
NCBI Official Symbol: | NCR3 |
NCBI Official Synonym Symbols: | 1C7; MALS; CD337; LY117; NKp30 |
NCBI Protein Information: | natural cytotoxicity triggering receptor 3; NK-p30; lymphocyte antigen 117; activating NK-A1 receptor; activating natural killer receptor p30; natural killer cell p30-related protein |
UniProt Protein Name: | Natural cytotoxicity triggering receptor 3 |
UniProt Synonym Protein Names: | Activating natural killer receptor p30; Natural killer cell p30-related protein; NK-p30; NKp30; CD_antigen: CD337 |
Protein Family: | Natural cytotoxicity triggering receptor |
UniProt Gene Name: | NCR3 |
UniProt Entry Name: | NCTR3_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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