NCK2 Antibody (PACO05518)
- SKU:
- PACO05518
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | NCK2 Antibody (PACO05518) |
抗体コード: | PACO05518 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:10000, IHC:1:100-1:300 |
反応性: | Human, Mouse |
免疫原: | Synthesized peptide derived from the C-terminal region of human Nck-2. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | NCK2; GRB4; Cytoplasmic protein NCK2; Growth factor receptor-bound protein 4; NCK adaptor protein 2; Nck-2; SH2/SH3 adaptor protein NCK-β |
UniProt Protein Function: | NCK2: Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q12 Cellular Component: endoplasmic reticulum; cytoplasm; vesicle membrane; cytosol Molecular Function:protein binding; receptor signaling complex scaffold activity; SH3/SH2 adaptor activity; cytoskeletal adaptor activity Biological Process: epidermal growth factor receptor signaling pathway; lamellipodium biogenesis; axon guidance; cell migration; T cell activation; positive regulation of signal transduction; regulation of epidermal growth factor receptor activity; negative regulation of peptidyl-serine phosphorylation; signal complex assembly; actin filament organization; signal transduction; regulation of translation; negative regulation of cell proliferation; positive regulation of actin filament polymerization; ephrin receptor signaling pathway; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; vascular endothelial growth factor receptor signaling pathway |
NCBI Summary: | This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43639 |
NCBI GenInfo Identifier: | 20532395 |
NCBI Gene ID: | 8440 |
NCBI Accession: | O43639.2 |
UniProt Secondary Accession: | O43639,Q9BWN9, Q9UIC3, D3DVK1, |
UniProt Related Accession: | O43639 |
Molecular Weight: | 380 |
NCBI Full Name: | Cytoplasmic protein NCK2 |
NCBI Synonym Full Names: | NCK adaptor protein 2 |
NCBI Official Symbol: | NCK2 |
NCBI Official Synonym Symbols: | GRB4; NCKbeta |
NCBI Protein Information: | cytoplasmic protein NCK2; SH2/SH3 adaptor protein NCK-beta; growth factor receptor-bound protein 4; noncatalytic region of tyrosine kinase, beta |
UniProt Protein Name: | Cytoplasmic protein NCK2 |
UniProt Synonym Protein Names: | Growth factor receptor-bound protein 4; NCK adaptor protein 2; Nck-2; SH2/SH3 adaptor protein NCK-beta |
Protein Family: | Cytoplasmic protein |
UniProt Gene Name: | NCK2 |
UniProt Entry Name: | NCK2_HUMAN |