NBN (Ab-343) Antibody (PACO22891)
- SKU:
- PACO22891
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | NBN (Ab-343) Antibody (PACO22891) |
抗体コード: | PACO22891 |
サイズ: | 100ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:1000, IHC:1:50-1:200 |
反応性: | Human |
免疫原: | Peptide sequence around aa.341~345 (S-L-S-Q-G) derived from Human p95/NBS1. |
憲法: | Liquid |
ストレージバッファ: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
精製方法: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from Jurkat cells using p95/NBS1(Ab-343) Antibody and the same antibody preincubated with blocking peptide. | |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p95/NBS1(Ab-343) Antibody(left) or the same antibody preincubated with blocking peptide(right). |
バックグラウンド: | Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. |
シノニム: | NBN |
UniProt Protein Function: | NBS1: a member of the MRE11/RAD50 double-strand break repair complex. Involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. Mutation results in the Nijmegen breakage syndrome (NBS), an autosomal recessive chromosomal instability syndrome. |
UniProt Protein Details: | Protein type:Cell cycle regulation; DNA repair, damage Chromosomal Location of Human Ortholog: 8q21 Cellular Component: cytosol; Mre11 complex; nuclear chromosome, telomeric region; nuclear inclusion body; nucleolus; nucleoplasm; nucleus; PML body; replication fork Molecular Function:ATP-dependent DNA helicase activity; damaged DNA binding; protein binding; protein N-terminus binding; transcription factor binding Biological Process: blastocyst growth; cell cycle arrest; cell proliferation; DNA damage checkpoint; DNA damage response, signal transduction by p53 class mediator; DNA duplex unwinding; DNA repair; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; double-strand break repair via synthesis-dependent strand annealing; isotype switching; meiotic cell cycle; mitotic cell cycle checkpoint; mitotic cell cycle G2/M transition DNA damage checkpoint; neuromuscular process controlling balance; positive regulation of kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of telomere maintenance; regulation of DNA replication initiation; telomere maintenance; telomeric 3' overhang formation Disease: Aplastic Anemia; Leukemia, Acute Lymphoblastic; Nijmegen Breakage Syndrome |
NCBI Summary: | Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008] |
UniProt Code: | O60934 |
NCBI GenInfo Identifier: | 74762960 |
NCBI Gene ID: | 4683 |
NCBI Accession: | O60934.1 |
UniProt Secondary Accession: | O60934,O60672, Q32NF7, Q53FM6, Q63HR6, Q7LDM2, B2R626 B2RNC5, |
UniProt Related Accession: | O60934 |
Molecular Weight: | 84,959 Da |
NCBI Full Name: | Nibrin |
NCBI Synonym Full Names: | nibrin |
NCBI Official Symbol: | NBN |
NCBI Official Synonym Symbols: | ATV; NBS; P95; NBS1; AT-V1; AT-V2 |
NCBI Protein Information: | nibrin |
UniProt Protein Name: | Nibrin |
UniProt Synonym Protein Names: | Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1 |
Protein Family: | Nibrin |
UniProt Gene Name: | NBN |
UniProt Entry Name: | NBN_HUMAN |
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