NANOG Antibody, Biotin conjugated (PACO42197)
- SKU:
- PACO42197
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | NANOG Antibody, Biotin conjugated (PACO42197) |
抗体コード: | PACO42197 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Homeobox protein NANOG protein (1-305AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. |
シノニム: | Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog), NANOG |
UniProt Protein Function: | NANOG: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, promotes cells to enter into S phase and proliferation. Interacts with SMAD1 and SALL4. Expressed in testicular carcinoma and derived germ cell tumors. Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes. Belongs to the Nanog homeobox family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding; Cell development/differentiation Chromosomal Location of Human Ortholog: 12p13.31 Cellular Component: nucleoplasm; nucleolus; nucleus Molecular Function:DNA binding; chromatin binding; transcription factor activity; transcription corepressor activity Biological Process: response to retinoic acid; gonad development; transcription, DNA-dependent; somatic stem cell maintenance; stem cell division; endodermal cell fate specification; stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mitotic cell cycle; embryonic pattern specification; mesodermal cell fate commitment; negative regulation of cell fate commitment; negative regulation of BMP signaling pathway; cell proliferation; regulation of transcription, DNA-dependent; regulation of gene expression; regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; cell differentiation |
NCBI Summary: | The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] |
UniProt Code: | Q9H9S0 |
NCBI GenInfo Identifier: | 118573073 |
NCBI Gene ID: | 79923 |
NCBI Accession: | Q9H9S0.2 |
UniProt Secondary Accession: | Q9H9S0,Q2TTG0, Q6JZS5, D3DUU4, |
UniProt Related Accession: | Q9H9S0 |
Molecular Weight: | 305 |
NCBI Full Name: | Homeobox protein NANOG |
NCBI Synonym Full Names: | Nanog homeobox |
NCBI Official Symbol: | NANOG |
NCBI Protein Information: | homeobox protein NANOG; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48 |
UniProt Protein Name: | Homeobox protein NANOG |
UniProt Synonym Protein Names: | Homeobox transcription factor Nanog; hNanog |
Protein Family: | NANOG neighbor homeobox |
UniProt Gene Name: | NANOG |
UniProt Entry Name: | NANOG_HUMAN |