MYL2 Antibody, HRP conjugated (PACO32813)
- SKU:
- PACO32813
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | MYL2 Antibody, HRP conjugated (PACO32813) |
抗体コード: | PACO32813 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Myosin regulatory light chain 2, ventricular/cardiac muscle isoform protein (8-164AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force. During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly. |
シノニム: | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Cardiac myosin light chain 2) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v) (Ventricular myosin light chain 2), MYL2, MLC2 |
UniProt Protein Function: | MRLC2V: myosin regulatory light chain 2, ventricular/cardiac muscle isoform. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. |
UniProt Protein Details: | Protein type:Contractile Chromosomal Location of Human Ortholog: 12q24.11 Cellular Component: sarcomere; cytoskeleton; myofibril; cytosol; myosin complex; A band; actin cytoskeleton Molecular Function:actin monomer binding; protein binding; structural constituent of muscle; calcium ion binding; myosin heavy chain binding Biological Process: muscle cell fate specification; heart contraction; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; cardiac myofibril assembly; negative regulation of cell growth; muscle fiber development; muscle filament sliding; cardiac muscle contraction; post-embryonic development Disease: Cardiomyopathy, Familial Hypertrophic, 10 |
NCBI Summary: | Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] |
UniProt Code: | P10916 |
NCBI GenInfo Identifier: | 6166556 |
NCBI Gene ID: | 4633 |
NCBI Accession: | P10916.3 |
UniProt Secondary Accession: | P10916,Q16123, |
UniProt Related Accession: | P10916 |
Molecular Weight: | 166 |
NCBI Full Name: | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform |
NCBI Synonym Full Names: | myosin, light chain 2, regulatory, cardiac, slow |
NCBI Official Symbol: | MYL2 |
NCBI Official Synonym Symbols: | MLC2; CMH10 |
NCBI Protein Information: | myosin regulatory light chain 2, ventricular/cardiac muscle isoform; MLC-2; MLC-2v; RLC of myosin; myosin light chain 2; regulatory light chain of myosin; cardiac ventricular myosin light chain 2; slow cardiac myosin regulatory light chain 2; myosin, light polypeptide 2, regulatory, cardiac, slow |
UniProt Protein Name: | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform |
Protein Family: | Myosin regulatory |
UniProt Gene Name: | MYL2 |
UniProt Entry Name: | MLRV_HUMAN |