MYBBP1A Antibody (PACO20055)
- SKU:
- PACO20055
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MYBBP1A Antibody (PACO20055) |
抗体コード: | PACO20055 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human |
免疫原: | Synthetic peptide of human MYBBP1A |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO20055(MYBBP1A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO20055(MYBBP1A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. |
シノニム: | MYB binding protein (P160) 1a |
UniProt Protein Function: | MYBBP1A: may activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PGC-1 (PPAR gamma coactivator-1): this interaction is abrogated when PGC-1 is phosphorylated by ERK1. Binds to and stimulates transcription by AhR. Binds to KPNA2. Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on exportin 1. Predominantly nucleolar. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Nucleolus; DNA replication; DNA-binding; RNA-binding Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: NLS-dependent protein nuclear import complex; intracellular membrane-bound organelle; membrane; cytoplasm; nucleolus; nucleus Molecular Function:protein binding; sequence-specific DNA binding; DNA-directed DNA polymerase activity; transcription corepressor activity; transcription factor binding Biological Process: osteoblast differentiation; cellular response to glucose starvation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleocytoplasmic transport; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent |
NCBI Summary: | This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
UniProt Code: | Q9BQG0 |
NCBI GenInfo Identifier: | 71153825 |
NCBI Gene ID: | 10514 |
NCBI Accession: | Q9BQG0.2 |
UniProt Secondary Accession: | Q9BQG0,Q86VM3, Q9BW49, Q9P0V5, Q9UF99, |
UniProt Related Accession: | Q9BQG0 |
Molecular Weight: | 1328 |
NCBI Full Name: | Myb-binding protein 1A |
NCBI Synonym Full Names: | MYB binding protein (P160) 1a |
NCBI Official Symbol: | MYBBP1A |
NCBI Official Synonym Symbols: | P160; PAP2 |
NCBI Protein Information: | myb-binding protein 1A; p53-activated protein-2 |
UniProt Protein Name: | Myb-binding protein 1A |
Protein Family: | Myb-binding protein |
UniProt Gene Name: | MYBBP1A |
UniProt Entry Name: | MBB1A_HUMAN |
Antibodies | ELISA Kits |
Anti-MYBBP1A Antibody (CAB4429) | Human MYBBP1A (Myb-binding protein 1A) ELISA Kit (HUFI07560) |
MYBBP1A Antibody (PACO10669) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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