MXD3 Antibody, Biotin conjugated (PACO28445)
- SKU:
- PACO28445
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | MXD3 Antibody, Biotin conjugated (PACO28445) |
抗体コード: | PACO28445 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Max dimerization protein 3 protein (1-206AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity). |
シノニム: | Max dimerization protein 3 (Max dimerizer 3) (Class C basic helix-loop-helix protein 13) (bHLHc13) (Max-associated protein 3) (Max-interacting transcriptional repressor MAD3) (Myx), MXD3, BHLHC13 MAD3 |
UniProt Protein Function: | MXD3: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 5q35.3 Molecular Function:protein binding |
NCBI Summary: | This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008] |
UniProt Code: | Q9BW11 |
NCBI GenInfo Identifier: | 74733390 |
NCBI Gene ID: | 83463 |
NCBI Accession: | Q9BW11.1 |
UniProt Secondary Accession: | Q9BW11,Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3, B4E0J1, |
UniProt Related Accession: | Q9BW11 |
Molecular Weight: | 42,821 Da |
NCBI Full Name: | Max dimerization protein 3 |
NCBI Synonym Full Names: | MAX dimerization protein 3 |
NCBI Official Symbol: | MXD3 |
NCBI Official Synonym Symbols: | MYX; MAD3; BHLHC13 |
NCBI Protein Information: | max dimerization protein 3 |
UniProt Protein Name: | Max dimerization protein 3 |
UniProt Synonym Protein Names: | Class C basic helix-loop-helix protein 13; bHLHc13; Max-associated protein 3; Max-interacting transcriptional repressor MAD3; Myx |
Protein Family: | Max dimerization protein |
UniProt Gene Name: | MXD3 |
UniProt Entry Name: | MAD3_HUMAN |