MPI Antibody (PACO10554)
- SKU:
- PACO10554
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MPI Antibody (PACO10554) |
抗体コード: | PACO10554 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human MPI |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | mannose phosphate isomerase;MPI;FLJ39201;PMI;PMI1 ; |
UniProt Protein Function: | MPI: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. Defects in MPI are the cause of congenital disorder of glycosylation type 1B (CDG1B); also known as carbohydrate-deficient glycoprotein syndrome type Ib (CDGS1B). Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under- glycosylated serum glycoproteins. CDG1B is clinically characterized by protein-losing enteropathy. Belongs to the mannose-6-phosphate isomerase type 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 5.3.1.8; Isomerase Chromosomal Location of Human Ortholog: 15q24.1 Cellular Component: cytosol Molecular Function:mannose-6-phosphate isomerase activity Biological Process: GDP-mannose biosynthetic process Disease: Congenital Disorder Of Glycosylation, Type Ib |
NCBI Summary: | Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
UniProt Code: | P34949 |
NCBI GenInfo Identifier: | 462567 |
NCBI Gene ID: | 4351 |
NCBI Accession: | P34949.2 |
UniProt Secondary Accession: | P34949,Q96AB0, A8K8K9, |
UniProt Related Accession: | P34949 |
Molecular Weight: | 39,834 Da |
NCBI Full Name: | Mannose-6-phosphate isomerase |
NCBI Synonym Full Names: | mannose phosphate isomerase |
NCBI Official Symbol: | MPI |
NCBI Official Synonym Symbols: | PMI; PMI1; CDG1B |
NCBI Protein Information: | mannose-6-phosphate isomerase |
UniProt Protein Name: | Mannose-6-phosphate isomerase |
UniProt Synonym Protein Names: | Phosphohexomutase; Phosphomannose isomerase; PMI |
Protein Family: | Mannose-6-phosphate isomerase |
UniProt Gene Name: | MPI |
UniProt Entry Name: | MPI_HUMAN |