MLKL Antibody, Biotin conjugated (PACO39685)
- SKU:
- PACO39685
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | MLKL Antibody, Biotin conjugated (PACO39685) |
抗体コード: | PACO39685 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Mixed lineage kinase domain-like protein (1-471AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. |
シノニム: | Mixed lineage kinase domain-like protein (hMLKL), MLKL |
UniProt Protein Function: | MLKL: Belongs to the protein kinase superfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; TKL-Unique family Chromosomal Location of Human Ortholog: 16q23.1 Cellular Component: cytoplasm; cytosol; plasma membrane Molecular Function:ATP binding; protein binding; protein complex binding; protein kinase activity; signal transducer activity Biological Process: protein amino acid phosphorylation |
NCBI Summary: | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015] |
UniProt Code: | Q8NB16 |
NCBI GenInfo Identifier: | 74762545 |
NCBI Gene ID: | 197259 |
NCBI Accession: | Q8NB16.1 |
UniProt Secondary Accession: | Q8NB16,Q8N6V0, A6NCE4, |
UniProt Related Accession: | Q8NB16 |
Molecular Weight: | 54kDa |
NCBI Full Name: | Mixed lineage kinase domain-like protein |
NCBI Synonym Full Names: | mixed lineage kinase domain like pseudokinase |
NCBI Official Symbol: | MLKL |
NCBI Official Synonym Symbols: | hMLKL |
NCBI Protein Information: | mixed lineage kinase domain-like protein |
UniProt Protein Name: | Mixed lineage kinase domain-like protein |
UniProt Gene Name: | MLKL |