MICU2 Antibody, Biotin conjugated (PACO53493)
- SKU:
- PACO53493
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | MICU2 Antibody, Biotin conjugated (PACO53493) |
抗体コード: | PACO53493 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Calcium uptake protein 2, mitochondrial protein (26-247AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering. |
シノニム: | Calcium uptake protein 2, mitochondrial (EF-hand domain-containing family member A1), MICU2, EFHA1 |
UniProt Protein Function: | MICU2: Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU). Component of a complex, at least composed of MCU, MICU1 and MICU2 |
UniProt Protein Details: | Protein type:Calcium-binding; Mitochondrial Chromosomal Location of Human Ortholog: 13q12.11 Cellular Component: mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion; nucleus Molecular Function:protein binding; protein heterodimerization activity Biological Process: mitochondrial calcium ion homeostasis; mitochondrial calcium ion transport; reduction of mitochondrial calcium ion concentration |
UniProt Code: | Q8IYU8 |
NCBI GenInfo Identifier: | 115502157 |
NCBI Gene ID: | 221154 |
NCBI Accession: | Q8IYU8.2 |
UniProt Secondary Accession: | Q8IYU8,Q8N0T6, Q8NAX8, |
UniProt Related Accession: | Q8IYU8 |
Molecular Weight: | 50kDa |
NCBI Full Name: | Calcium uptake protein 2, mitochondrial |
NCBI Synonym Full Names: | mitochondrial calcium uptake 2 |
NCBI Official Symbol: | MICU2 |
NCBI Official Synonym Symbols: | EFHA1; 1110008L20Rik |
NCBI Protein Information: | calcium uptake protein 2, mitochondrial |
UniProt Protein Name: | Calcium uptake protein 2, mitochondrial |
UniProt Synonym Protein Names: | EF-hand domain-containing family member A1 |
Protein Family: | Calcium uptake protein |
UniProt Gene Name: | MICU2 |