MEIS2 Antibody (PACO53694)
- SKU:
- PACO53694
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MEIS2 Antibody (PACO53694) |
抗体コード: | PACO53694 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Homeobox protein Meis2 protein (377-470AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Mouse liver tissue. All lanes: MEIS2 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 52, 44, 33, 34, 42, 43 kDa. Observed band size: 52 kDa. | |
Immunofluorescent analysis of Hela cells using PACO53694 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription. |
シノニム: | Homeobox protein Meis2 (Meis1-related protein 1), MEIS2, MRG1 |
NCBI Summary: | This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O14770 |
NCBI GenInfo Identifier: | 33989064 |
NCBI Gene ID: | 4212 |
NCBI Accession: | BC001516 |
UniProt Secondary Accession: | O14770,Q96DI2, Q96KI4, Q96KI5, Q9NRS1, Q9NRS2, Q9NRS3 A6NJI5, A8MWD5, B3KP98, B3KPQ6, |
UniProt Related Accession: | O14770 |
Molecular Weight: | 42,272 Da |
NCBI Full Name: | Homo sapiens Meis homeobox 2, mRNA |
NCBI Synonym Full Names: | Meis homeobox 2 |
NCBI Official Symbol: | MEIS2 |
NCBI Official Synonym Symbols: | MRG1; HsT18361 |
NCBI Protein Information: | homeobox protein Meis2 |
UniProt Protein Name: | |
Protein Family: | Homeobox protein |
UniProt Gene Name: |