MED7 Antibody (PACO28210)
- SKU:
- PACO28210
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MED7 Antibody (PACO28210) |
抗体コード: | PACO28210 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Mediator of RNA polymerase II transcription subunit 7 protein (1-233AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: MED7 antibody at 6µg/ml Lane 1: Jurkat whole cell lysate Lane 2: Hela whole cell lysate Lane 3: Mouse thymus tissue Lane 4: NIH/3T3 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 28 kDa Observed band size: 28 kDa . |
バックグラウンド: | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
シノニム: | Mediator of RNA polymerase II transcription subunit 7 (hMED7) (Activator-recruited cofactor 34 kDa component) (ARC34) (Cofactor required for Sp1 transcriptional activation subunit 9) (CRSP complex subunit 9) (Mediator complex subunit 7) (RNA polymerase transcriptional regulation mediator subunit 7 homolog) (Transcriptional coactivator CRSP33), MED7, ARC34 CRSP9 |
UniProt Protein Function: | MED7: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 7 family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5q33.3 Cellular Component: nucleoplasm; Srb-mediator complex; transcription factor complex Molecular Function:protein binding; transcription coactivator activity Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter |
NCBI Summary: | The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43513 |
NCBI GenInfo Identifier: | 29337159 |
NCBI Gene ID: | 9443 |
NCBI Accession: | O43513.1 |
UniProt Related Accession: | O43513 |
Molecular Weight: | 27,245 Da |
NCBI Full Name: | Mediator of RNA polymerase II transcription subunit 7 |
NCBI Synonym Full Names: | mediator complex subunit 7 |
NCBI Official Symbol: | MED7 |
NCBI Official Synonym Symbols: | ARC34; CRSP9; CRSP33 |
NCBI Protein Information: | mediator of RNA polymerase II transcription subunit 7 |
UniProt Protein Name: | Mediator of RNA polymerase II transcription subunit 7 |
UniProt Synonym Protein Names: | Activator-recruited cofactor 34 kDa component; ARC34; Cofactor required for Sp1 transcriptional activation subunit 9; CRSP complex subunit 9; Mediator complex subunit 7; RNA polymerase transcriptional regulation mediator subunit 7 homolog; Transcriptional coactivator CRSP33 |
Protein Family: | Putative mediator of RNA polymerase II transcription |
UniProt Gene Name: | MED7 |
UniProt Entry Name: | MED7_HUMAN |
Antibodies |
Anti-MED7 Antibody (CAB16088) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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