Description
抗体名: | MCTS1 Antibody (PACO16661) |
抗体コード: | PACO16661 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
反応性: | Human |
免疫原: | Fusion protein of human MCTS1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16661(MCTS1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Jurkat cells, K562 cells, PC3 cells, A549 cells, Primary antibody: PACO16661(MCTS1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16661(MCTS1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | MCTS1 (malignant T cell amplified sequence 1), also known as MCT1, is a 181 amino acid, protein that is ubiquitously expressed and localizes to the cytoplasm of cells. MCTS1 may play a role in cell cycle regulation by decreasing cell doubling time and by shortening the duration of G1 transit time and G1/S transition. The protein level of Cdk4 and Cdk6 kinases activity and cyclin D1 is enhanced by expression of MCTS1. As a translation enhancer, MCTS1 recruits DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile. MCTS1 promotes lymphoid tumor development and contributes to the pathogenesis and progression of breast cancer. MCTS1 positively regulates phosphorylation of ERK1 and ERK2. |
シノニム: | malignant T cell amplified sequence 1 |
UniProt Protein Function: | MCTS1: Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma- irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Belongs to the MCTS1 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: Xq24 Cellular Component: cytoplasm; plasma membrane Biological Process: formation of translation preinitiation complex; positive regulation of cell proliferation; ribosome disassembly |
UniProt Code: | Q9ULC4 |
NCBI GenInfo Identifier: | 74735052 |
NCBI Gene ID: | 28985 |
NCBI Accession: | Q9ULC4.1 |
UniProt Secondary Accession: | Q9ULC4,Q502X6, B4DGY2, |
UniProt Related Accession: | Q9ULC4 |
Molecular Weight: | 20,550 Da |
NCBI Full Name: | Malignant T-cell-amplified sequence 1 |
NCBI Synonym Full Names: | MCTS1, re-initiation and release factor |
NCBI Official Symbol: | MCTS1 |
NCBI Official Synonym Symbols: | MCT1; MCT-1 |
NCBI Protein Information: | malignant T-cell-amplified sequence 1 |
UniProt Protein Name: | Malignant T-cell-amplified sequence 1 |
UniProt Synonym Protein Names: | Multiple copies T-cell malignancies |
Protein Family: | Malignant T-cell-amplified sequence |
UniProt Gene Name: | MCTS1 |
UniProt Entry Name: | MCTS1_HUMAN |
Antibodies | ELISA Kits |
Anti-MCTS1 Antibody (CAB9061) | Human MCTS1 / Malignant T cell amplified sequence 1 ELISA Kit |
Human Malignant T cell-amplified sequence 1 (MCTS1) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |