MCM8 Antibody (PACO10425)
- SKU:
- PACO10425
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MCM8 Antibody (PACO10425) |
抗体コード: | PACO10425 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human MCM8 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | minichromosome maintenance complex component 8;MCM8;C20orf154;MGC119522;MGC119523;MGC12866;MGC4816;REC;dJ967N21.5 ; |
UniProt Protein Function: | MCM8: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle. Belongs to the MCM family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell cycle regulation; EC 3.6.4.12 Chromosomal Location of Human Ortholog: 20p12.3 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; DNA binding; helicase activity; ATP binding Biological Process: male gamete generation; female gamete generation; mitotic cell cycle; DNA strand elongation during DNA replication; DNA replication; response to DNA damage stimulus; double-strand break repair via homologous recombination; G1/S transition of mitotic cell cycle Disease: Premature Ovarian Failure 10 |
NCBI Summary: | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013] |
UniProt Code: | Q9UJA3 |
NCBI GenInfo Identifier: | 27805609 |
NCBI Gene ID: | 84515 |
NCBI Accession: | Q9UJA3.2 |
UniProt Secondary Accession: | Q9UJA3,Q495R4, Q495R6, Q495R7, Q86US4, Q969I5, B2RBG7 D3DW08, E7EQU7, |
UniProt Related Accession: | Q9UJA3 |
Molecular Weight: | 840 |
NCBI Full Name: | DNA helicase MCM8 |
NCBI Synonym Full Names: | minichromosome maintenance complex component 8 |
NCBI Official Symbol: | MCM8 |
NCBI Official Synonym Symbols: | C20orf154; dJ967N21.5 |
NCBI Protein Information: | DNA helicase MCM8; REC homolog; DNA replication licensing factor MCM8; MCM8 minichromosome maintenance deficient 8 |
UniProt Protein Name: | DNA helicase MCM8 |
UniProt Synonym Protein Names: | Minichromosome maintenance 8 |
Protein Family: | DNA helicase |
UniProt Gene Name: | MCM8 |
UniProt Entry Name: | MCM8_HUMAN |