UniProt Protein Function: | MCM3: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for DNA replication and cell proliferation. |
UniProt Protein Details: | Protein type:EC 3.6.4.12; DNA replication Chromosomal Location of Human Ortholog: 6p12 Cellular Component: nucleoplasm; centrosome; alpha DNA polymerase:primase complex; membrane; intracellular membrane-bound organelle; MCM complex; perinuclear region of cytoplasm; nucleus Molecular Function:DNA helicase activity; protein binding; DNA binding; ATP binding Biological Process: DNA replication initiation; mitotic cell cycle; DNA strand elongation during DNA replication; DNA replication; DNA duplex unwinding; G1/S transition of mitotic cell cycle |
NCBI Summary: | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012] |
UniProt Code: | P25205 |
NCBI GenInfo Identifier: | 19857543 |
NCBI Gene ID: | 4172 |
NCBI Accession: | P25205.3 |
UniProt Secondary Accession: | P25205,Q92660, Q9BTR3, Q9NUE7, B4DWW4, |
UniProt Related Accession: | P25205 |
Molecular Weight: | 808 |
NCBI Full Name: | DNA replication licensing factor MCM3 |
NCBI Synonym Full Names: | minichromosome maintenance complex component 3 |
NCBI Official Symbol: | MCM3 |
NCBI Official Synonym Symbols: | HCC5; P1.h; RLFB; P1-MCM3 |
NCBI Protein Information: | DNA replication licensing factor MCM3; p102; RLF subunit beta; hRlf beta subunit; DNA replication factor MCM3; cervical cancer proto-oncogene 5; minichromosome maintenance deficient 3; replication licensing factor, beta subunit; MCM3 minichromosome mainte |
UniProt Protein Name: | DNA replication licensing factor MCM3 |
UniProt Synonym Protein Names: | DNA polymerase alpha holoenzyme-associated protein P1; P1-MCM3; RLF subunit beta; p102 |
Protein Family: | DNA replication licensing factor |
UniProt Gene Name: | MCM3 |
UniProt Entry Name: | MCM3_HUMAN |