MAT1A Antibody (PACO13796)
- SKU:
- PACO13796
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MAT1A Antibody (PACO13796) |
抗体コード: | PACO13796 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human MAT1A |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: PACO13796(MAT1A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
バックグラウンド: | This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. |
シノニム: | methionine adenosyltransferase I, alpha |
UniProt Protein Function: | MAT1A: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. Defects in MAT1A are the cause of methionine adenosyltransferase deficiency (MATD); also called MAT I/III deficiency. MATD is an inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity. Belongs to the AdoMet synthase family. |
UniProt Protein Details: | Protein type:EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - cysteine and methionine; Transferase Chromosomal Location of Human Ortholog: 10q22 Cellular Component: cytosol Molecular Function:methionine adenosyltransferase activity Biological Process: amino acid metabolic process; methylation; selenium metabolic process; sulfur amino acid metabolic process Disease: Methionine Adenosyltransferase Deficiency |
NCBI Summary: | This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q00266 |
NCBI GenInfo Identifier: | 417297 |
NCBI Gene ID: | 4143 |
NCBI Accession: | Q00266.2 |
UniProt Secondary Accession: | Q00266,Q5QP09, D3DWD5, |
UniProt Related Accession: | Q00266 |
Molecular Weight: | 43,648 Da |
NCBI Full Name: | S-adenosylmethionine synthase isoform type-1 |
NCBI Synonym Full Names: | methionine adenosyltransferase 1A |
NCBI Official Symbol: | MAT1A |
NCBI Official Synonym Symbols: | MAT; SAMS; MATA1; SAMS1 |
NCBI Protein Information: | S-adenosylmethionine synthase isoform type-1 |
UniProt Protein Name: | S-adenosylmethionine synthase isoform type-1 |
UniProt Synonym Protein Names: | Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/III |
Protein Family: | S-adenosylmethionine synthase |
UniProt Gene Name: | MAT1A |
UniProt Entry Name: | METK1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |