MAGEA6 Antibody (PACO43814)
- SKU:
- PACO43814
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MAGEA6 Antibody (PACO43814) |
抗体コード: | PACO43814 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
反応性: | Human, Rat |
免疫原: | Recombinant Human Melanoma-associated antigen 6 protein (75-314AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: MAGEA6 antibody at 7µg/ml Lane 1: Rat brain tissue Lane 2: Rat gonad tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 35 kDa Observed band size: 35 kDa | |
Immunohistochemistry of paraffin-embedded human lung cancer using PACO43814 at dilution of 1:100 | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO43814 at dilution of 1:100 |
バックグラウンド: | Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. |
シノニム: | Melanoma-associated antigen 6 (Cancer/testis antigen 1.6) (CT1.6) (MAGE-6 antigen) (MAGE3B antigen), MAGEA6, MAGE6 |
UniProt Protein Function: | Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. |
NCBI Summary: | This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
UniProt Code: | P43360 |
NCBI GenInfo Identifier: | 4885469 |
NCBI Gene ID: | 4105 |
NCBI Accession: | NP_005354.1 |
UniProt Secondary Accession: | P43360,Q6NW44, A8IF93, |
UniProt Related Accession: | P43360 |
Molecular Weight: | 34 |
NCBI Full Name: | melanoma-associated antigen 6 |
NCBI Synonym Full Names: | MAGE family member A6 |
NCBI Official Symbol: | MAGEA6 |
NCBI Official Synonym Symbols: | CT1.6; MAGE6; MAGE3B; MAGE-3b |
NCBI Protein Information: | melanoma-associated antigen 6 |
UniProt Protein Name: | Melanoma-associated antigen 6 |
UniProt Synonym Protein Names: | Cancer/testis antigen 1.6; CT1.6; MAGE-6 antigen; MAGE3B antigen |
UniProt Gene Name: | MAGEA6 |